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EIF4A3 eukaryotic translation initiation factor 4A3 [ Homo sapiens (human) ]

Gene ID: 9775, updated on 6-Sep-2021

Summary

Official Symbol
EIF4A3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4A3provided by HGNC
Primary source
HGNC:HGNC:18683
See related
Ensembl:ENSG00000141543 MIM:608546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fal1; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eIF4A-III; eIF-4A-III
Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 66.0), adrenal (RPKM 43.4) and 25 other tissues See more
Orthologs
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Genomic context

See EIF4A3 in Genome Data Viewer
Location:
17q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (80134369..80147128, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78108168..78120927, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 40 Neighboring gene microRNA 1268b Neighboring gene alpha glucosidase Neighboring gene caspase recruitment domain family member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene solute carrier family 26 member 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A3 (EIF4A3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A3 (EIF4A3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A3 (EIF4A3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A3 (EIF4A3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0111, MGC10862, DKFZp686O16189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA stem-loop binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
enables selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to selenite ion IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of selenocysteine incorporation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
part_of exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic initiation factor 4A-III
Names
ATP-dependent RNA helicase DDX48
ATP-dependent RNA helicase eIF4A-3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
DEAD box protein 48
NMP 265
eukaryotic initiation factor 4A-like NUK-34
nuclear matrix protein 265
NP_055555.1
XP_011523824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046916.1 RefSeqGene

    Range
    5056..17815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1284

mRNA and Protein(s)

  1. NM_014740.4NP_055555.1  eukaryotic initiation factor 4A-III

    See identical proteins and their annotated locations for NP_055555.1

    Status: REVIEWED

    Source sequence(s)
    AC087741, BC004386, DA667983
    Consensus CDS
    CCDS11767.1
    UniProtKB/Swiss-Prot
    P38919
    UniProtKB/TrEMBL
    A0A024R8W0
    Related
    ENSP00000497641.1, ENST00000649764.2
    Conserved Domains (1) summary
    PTZ00424
    Location:35411
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    80134369..80147128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525522.2XP_011523824.1  eukaryotic initiation factor 4A-III isoform X1

    Related
    ENSP00000460439.2, ENST00000576547.2
    Conserved Domains (3) summary
    PTZ00424
    Location:35390
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:230359
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:40219
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
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