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CD151 CD151 molecule (Raph blood group) [ Homo sapiens (human) ]

Gene ID: 977, updated on 7-Jun-2020

Summary

Official Symbol
CD151provided by HGNC
Official Full Name
CD151 molecule (Raph blood group)provided by HGNC
Primary source
HGNC:HGNC:1630
See related
Ensembl:ENSG00000177697 MIM:602243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues See more
Orthologs

Genomic context

See CD151 in Genome Data Viewer
Location:
11p15.5
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (832952..838835)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (832952..838840)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tetraspanin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Nephropathy with pretibial epidermolysis bullosa and deafness
MedGen: C1836823 OMIM: 609057 GeneReviews: Not available
Compare labs
RAPH BLOOD GROUP SYSTEM
MedGen: C1867341 OMIM: 179620 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
Nef nef HIV-1 Nef downregulates the cell surface expression of CD151 (TSPAN24) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemidesmosome assembly TAS
Traceable Author Statement
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells IDA
Inferred from Direct Assay
more info
PubMed 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD151 antigen
Names
CD151 antigen (Raph blood group)
hemidesmosomal tetraspanin CD151
membrane glycoprotein SFA-1
platelet surface glycoprotein gp27
platelet-endothelial cell tetraspan antigen 3
platelet-endothelial tetraspan antigen 3
tetraspanin-24
tspan-24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007478.1 RefSeqGene

    Range
    5001..10880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039490.1NP_001034579.1  CD151 antigen

    See identical proteins and their annotated locations for NP_001034579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment of sequence in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374, BQ957432
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    P48509
    UniProtKB/TrEMBL
    A0A024RCB3, Q6ZNZ0
    Conserved Domains (1) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  2. NM_004357.5NP_004348.2  CD151 antigen

    See identical proteins and their annotated locations for NP_004348.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    P48509
    UniProtKB/TrEMBL
    A0A024RCB3, Q6ZNZ0
    Related
    ENSP00000380565.3, ENST00000397420.9
    Conserved Domains (1) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  3. NM_139029.1NP_620598.1  CD151 antigen

    See identical proteins and their annotated locations for NP_620598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374, BC013302
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    P48509
    UniProtKB/TrEMBL
    A0A024RCB3, Q6ZNZ0
    Related
    ENSP00000324101.4, ENST00000322008.9
    Conserved Domains (1) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
  4. NM_139030.3NP_620599.1  CD151 antigen

    See identical proteins and their annotated locations for NP_620599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    P48509
    UniProtKB/TrEMBL
    A0A024RCB3, Q6ZNZ0
    Related
    ENSP00000380566.1, ENST00000397421.5
    Conserved Domains (1) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    832952..838835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448780.1XP_024304548.1  CD151 antigen isoform X1

    Conserved Domains (1) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
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