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ADGRE5 adhesion G protein-coupled receptor E5 [ Homo sapiens (human) ]

Gene ID: 976, updated on 12-Oct-2019

Summary

Official Symbol
ADGRE5provided by HGNC
Official Full Name
adhesion G protein-coupled receptor E5provided by HGNC
Primary source
HGNC:HGNC:1711
See related
Ensembl:ENSG00000123146 MIM:601211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD97; TM7LN1
Summary
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Expression
Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues See more
Orthologs

Genomic context

See ADGRE5 in Genome Data Viewer
Location:
19p13.12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14381144..14408725)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14491403..14519537)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 231, pseudogene Neighboring gene long intergenic non-protein coding RNA 1841 Neighboring gene long intergenic non-protein coding RNA 1842 Neighboring gene DExD-box helicase 39A Neighboring gene Sharpr-MPRA regulatory region 3261 Neighboring gene protein kinase N1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CD97 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD97 antigen
Names
CD97 molecule
leukocyte antigen CD97
seven transmembrane helix receptor
seven-span transmembrane protein
seven-transmembrane, heterodimeric receptor associated with inflammation

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029253.1 RefSeqGene

    Range
    5301..32580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025160.2NP_001020331.1  CD97 antigen isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001020331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as CD97(EGF 1,2,3,5)) is shorter than isoform 1.
    Source sequence(s)
    AI890331, AK225655, AK292159, DC381605, DC414739
    Consensus CDS
    CCDS32930.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000349918.2, ENST00000357355.7
    Conserved Domains (4) summary
    smart00179
    Location:116148
    EGF_CA; Calcium-binding EGF-like domain
    pfam00002
    Location:495733
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:444487
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:160194
    EGF_CA; Calcium-binding EGF domain
  2. NM_001784.5NP_001775.2  CD97 antigen isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001775.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2, also known as CD97(EGF 1,2,5)) is shorter than isoform 1.
    Source sequence(s)
    AC008569
    Consensus CDS
    CCDS32931.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000351413.2, ENST00000358600.7
    Conserved Domains (4) summary
    smart00303
    Location:399449
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam07645
    Location:116150
    EGF_CA; Calcium-binding EGF domain
    cd14964
    Location:454478
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:451713
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_078481.4NP_510966.1  CD97 antigen isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_510966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CD97(EGF 1,2,3,4,5)).
    Source sequence(s)
    AI890331, AK314697, U76764
    Consensus CDS
    CCDS32929.1
    UniProtKB/Swiss-Prot
    P48960
    Related
    ENSP00000242786.4, ENST00000242786.6
    Conserved Domains (5) summary
    smart00179
    Location:116148
    EGF_CA; Calcium-binding EGF-like domain
    COG0477
    Location:608785
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
    pfam00002
    Location:544782
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:493536
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:160207
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14381144..14408725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528451.3XP_011526753.1  CD97 antigen isoform X1

    Conserved Domains (5) summary
    smart00179
    Location:116148
    EGF_CA; Calcium-binding EGF-like domain
    COG0477
    Location:608785
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
    pfam00002
    Location:544782
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:493536
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:160207
    EGF_CA; Calcium-binding EGF domain
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