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Adgre5 adhesion G protein-coupled receptor E5 [ Mus musculus (house mouse) ]

Gene ID: 26364, updated on 18-Apr-2024

Summary

Official Symbol
Adgre5provided by MGI
Official Full Name
adhesion G protein-coupled receptor E5provided by MGI
Primary source
MGI:MGI:1347095
See related
Ensembl:ENSMUSG00000002885 AllianceGenome:MGI:1347095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd97; TM7LN1
Summary
Predicted to enable G protein-coupled receptor activity and chondroitin sulfate binding activity. Acts upstream of or within positive regulation of synapse assembly. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 217.2), spleen adult (RPKM 95.9) and 14 other tissues See more
Orthologs
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Genomic context

Location:
8 C2; 8 40.22 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84449874..84467812, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83723245..83741311, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene protein kinase N1 Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86271935-86272044 Neighboring gene predicted gene, 46046 Neighboring gene STARR-positive B cell enhancer ABC_E10 Neighboring gene predicted gene, 42030

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor E5
Names
CD97 antigen
EGF-TM7 receptor
leukocyte antigen CD97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163029.2NP_001156501.1  adhesion G protein-coupled receptor E5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156501.1

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52610.1
    UniProtKB/TrEMBL
    A0A0D9SEG8, Q4FJS6
    Related
    ENSMUSP00000002964.8, ENSMUST00000002964.14
    Conserved Domains (3) summary
    pfam00002
    Location:432672
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:386424
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:120154
    EGF_CA; Calcium-binding EGF domain
  2. NM_001163030.2NP_001156502.1  adhesion G protein-coupled receptor E5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52611.1
    UniProtKB/Swiss-Prot
    Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
    UniProtKB/TrEMBL
    E9QMJ5
    Related
    ENSMUSP00000105427.3, ENSMUST00000109802.3
    Conserved Domains (3) summary
    pfam00002
    Location:481721
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:435473
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:120167
    EGF_CA; Calcium-binding EGF domain
  3. NM_001163031.2NP_001156503.1  adhesion G protein-coupled receptor E5 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001156503.1

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS52612.1
    UniProtKB/TrEMBL
    Q4FJS6, Q9DC42
    Related
    ENSMUSP00000128220.2, ENSMUST00000166939.8
    Conserved Domains (3) summary
    pfam00002
    Location:430670
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:384422
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:118152
    EGF_CA; Calcium-binding EGF domain
  4. NM_001414296.1NP_001401225.1  adhesion G protein-coupled receptor E5 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  5. NM_001414297.1NP_001401226.1  adhesion G protein-coupled receptor E5 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  6. NM_001414298.1NP_001401227.1  adhesion G protein-coupled receptor E5 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  7. NM_001414300.1NP_001401229.1  adhesion G protein-coupled receptor E5 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  8. NM_001414301.1NP_001401230.1  adhesion G protein-coupled receptor E5 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  9. NM_001414302.1NP_001401231.1  adhesion G protein-coupled receptor E5 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
  10. NM_011925.3NP_036055.2  adhesion G protein-coupled receptor E5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC164432
    Consensus CDS
    CCDS22461.1
    UniProtKB/Swiss-Prot
    Q923A1, Q9CVI5, Q9JLQ8, Q9Z0M6
    UniProtKB/TrEMBL
    E9QJS7
    Related
    ENSMUSP00000075240.7, ENSMUST00000075843.13
    Conserved Domains (3) summary
    pfam00002
    Location:526766
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:480518
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:165212
    EGF_CA; Calcium-binding EGF domain

RNA

  1. NR_183247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164432

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84449874..84467812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)