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SLK STE20 like kinase [ Homo sapiens (human) ]

Gene ID: 9748, updated on 9-Dec-2018

Summary

Official Symbol
SLKprovided by HGNC
Official Full Name
STE20 like kinaseprovided by HGNC
Primary source
HGNC:HGNC:11088
See related
Ensembl:ENSG00000065613 MIM:616563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOSK; STK2; se20-9; bA16H23.1
Expression
Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See SLK in Genome Data Viewer
Location:
10q24.33-q25.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (103967100..104029233)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105726943..105788991)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene STN1, CST complex subunit Neighboring gene Sharpr-MPRA regulatory region 190 Neighboring gene uncharacterized LOC102724351 Neighboring gene RNA, 7SL, cytoplasmic 524, pseudogene Neighboring gene collagen type XVII alpha 1 chain Neighboring gene microRNA 936 Neighboring gene SWI5 dependent homologous recombination repair protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
NHGRI GWA Catalog

Pathways from BioSystems

  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0204, MGC133067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
STE20-like serine/threonine-protein kinase
Names
CTCL tumor antigen se20-9
Long Ste20-like Kinase
SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase
SNF1 sucrose nonfermenting like kinase
STE20-related kinase
STE20-related serine/threonine-protein kinase
Ste20-related serine/threonine kinase
hSLK
serine/threonine-protein kinase 2
NP_001291672.1
NP_055535.2
XP_011538703.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304743.1NP_001291672.1  STE20-like serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001291672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AL138761, BC008697, BC047885, BC111565
    Consensus CDS
    CCDS76334.1
    UniProtKB/Swiss-Prot
    Q9H2G2
    Related
    ENSP00000336824.4, ENST00000335753.8
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:9891129
    PKK; Polo kinase kinase
  2. NM_014720.4NP_055535.2  STE20-like serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_055535.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF273048, AL138761, AL360170, BC047885
    Consensus CDS
    CCDS7553.1
    UniProtKB/Swiss-Prot
    Q9H2G2
    Related
    ENSP00000358770.3, ENST00000369755.3
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:10201160
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    103967100..104029233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540401.3XP_011538703.1  STE20-like serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:568708
    PKK; Polo kinase kinase
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