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Slk STE20-like kinase [ Mus musculus (house mouse) ]

Gene ID: 20874, updated on 9-May-2024

Summary

Official Symbol
Slkprovided by MGI
Official Full Name
STE20-like kinaseprovided by MGI
Primary source
MGI:MGI:103241
See related
Ensembl:ENSMUSG00000025060 AllianceGenome:MGI:103241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9A2; Etk4; SMAK; Stk2; mSLK; mKIAA0204
Summary
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in regulation of cell migration. Located in cell leading edge. Is expressed in several structures, including alimentary system; eye; genitourinary system; muscle tissue; and nervous system. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slk in Genome Data Viewer
Location:
19 C3- D1; 19 39.77 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47568458..47633685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47580019..47645246)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene STN1, CST complex subunit Neighboring gene predicted gene, 19557 Neighboring gene STARR-positive B cell enhancer ABC_E5709 Neighboring gene STARR-seq mESC enhancer starr_46366 Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_46367 Neighboring gene predicted gene, 26085

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
STE20-like serine/threonine-protein kinase
Names
STE20-related kinase SMAK
STE20-related serine/threonine-protein kinase
serine/threonine-protein kinase 2
NP_001158111.1
NP_033315.2
XP_006526890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164639.1NP_001158111.1  STE20-like serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001158111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC125075, AK029491, AK037798, AK051969, CD740818, CO431234
    Consensus CDS
    CCDS50465.1
    UniProtKB/TrEMBL
    A2RRK3
    Related
    ENSMUSP00000026043.6, ENSMUST00000026043.12
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:9871127
    PKK; Polo kinase kinase
  2. NM_009289.3NP_033315.2  STE20-like serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_033315.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234
    Consensus CDS
    CCDS38017.1
    UniProtKB/Swiss-Prot
    A2RRK4, O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41
    Related
    ENSMUSP00000049977.8, ENSMUST00000051691.8
    Conserved Domains (3) summary
    smart00220
    Location:34292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:10181158
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47568458..47633685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526827.5XP_006526890.1  STE20-like serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:2841112
    PTZ00121; MAEBL; Provisional
    pfam12474
    Location:9421082
    PKK; Polo kinase kinase
    cl21453
    Location:1233
    PKc_like; Protein Kinases, catalytic domain