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USP34 ubiquitin specific peptidase 34 [ Homo sapiens (human) ]

Gene ID: 9736, updated on 7-Aug-2022

Summary

Official Symbol
USP34provided by HGNC
Official Full Name
ubiquitin specific peptidase 34provided by HGNC
Primary source
HGNC:HGNC:20066
See related
Ensembl:ENSG00000115464 MIM:615295; AllianceGenome:HGNC:20066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.6), lymph node (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See USP34 in Genome Data Viewer
Location:
2p15
Exon count:
80
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (61187463..61471087, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (61193315..61476925, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (61414598..61698222, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374758 Neighboring gene C2orf74 divergent transcript Neighboring gene chromosome 2 open reading frame 74 Neighboring gene activator of HSP90 ATPase homolog 2, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13579 Neighboring gene small nucleolar RNA, H/ACA box 70B Neighboring gene Sharpr-MPRA regulatory region 6736 Neighboring gene uncharacterized LOC124907772 Neighboring gene exportin 1 Neighboring gene proteasome 26S subunit, non-ATPase 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43910, KIAA0570, KIAA0729, MGC104459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 34
Names
deubiquitinating enzyme 34
ubiquitin specific protease 34
ubiquitin thioesterase 34
ubiquitin thiolesterase 34
ubiquitin-specific-processing protease 34
NP_055524.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014709.4NP_055524.3  ubiquitin carboxyl-terminal hydrolase 34

    See identical proteins and their annotated locations for NP_055524.3

    Status: VALIDATED

    Source sequence(s)
    AB011142, AC016727, AC016894, AC018889, AK023171, AW293998, BX473680
    Consensus CDS
    CCDS42686.1
    UniProtKB/Swiss-Prot
    Q70CQ2, Q9UGA1
    Related
    ENSP00000381577.2, ENST00000398571.7
    Conserved Domains (2) summary
    cd02659
    Location:18922241
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:18942236
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    61187463..61471087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    61193315..61476925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)