Usp34 ubiquitin specific peptidase 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp34provided by MGI
Official Full Name: ubiquitin specific peptidase 34provided by MGI
Primary source: MGI:MGI:109473
See related: Ensembl:ENSMUSG00000056342 AllianceGenome:MGI:109473
Gene type: protein coding
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Murr2; A530081C03Rik
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 12.8), CNS E14 (RPKM 10.9) and 26 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 A3.2; 11 14.29 cM

Exon count:: 80

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (23256433..23440560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (23303185..23490560)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-kappaB Signaling.
Title: Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
data indicate that USP34 is required for osteogenic differentiation and bone formation.
Title: Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.
the role of USP34 on epithelial-mesenchymal (EMT) induction and its effects on mammary epithelial stem cells, was investigated.
Title: Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

AI450991 (e-PCR)
- UniSTS:160075

NoName (e-PCR)
- UniSTS:225269

NoName (e-PCR)
- UniSTS:236535

Homology

Homologs of the Usp34 gene: The Usp34 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 485 organisms have orthologs with human gene Usp34
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ubiquitin carboxyl-terminal hydrolase 34

Names: U2af1-rs1 region 2; deubiquitinating enzyme 34; ubiquitin specific protease 34; ubiquitin thioesterase 34; ubiquitin thiolesterase 34; ubiquitin-specific-processing protease 34

NP_001177330.2

EC 3.4.19.12

XP_006514628.1

EC 3.4.19.12

XP_006514629.1

EC 3.4.19.12

XP_006514630.1

EC 3.4.19.12

XP_017169806.1

EC 3.4.19.12

XP_030101492.1

EC 3.4.19.12

XP_030101493.1

EC 3.4.19.12

XP_036012290.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190401.2 → NP_001177330.2 ubiquitin carboxyl-terminal hydrolase 34

See identical proteins and their annotated locations for NP_001177330.2

Status: INFERRED

Source sequence(s)

AL672004, AL672049, AL772359, AL928722

Consensus CDS

CCDS56763.1

UniProtKB/Swiss-Prot

Q6ZQ93, Q8CCH0

Related

ENSMUSP00000137430.2, ENSMUST00000180046.8

Conserved Domains (2) summary

cd02659
Location:1929 → 2278

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:1931 → 2273

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

23256433..23440560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514566.4 → XP_006514629.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X2

Conserved Domains (1) summary

cd02659
Location:1918 → 2267

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_006514565.3 → XP_006514628.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X1

Conserved Domains (1) summary

cd02659
Location:1930 → 2279

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_006514567.3 → XP_006514630.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X4

Conserved Domains (1) summary

cd02659
Location:1930 → 2279

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_017314317.3 → XP_017169806.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X5

Conserved Domains (1) summary

cd02659
Location:1929 → 2278

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_036156397.1 → XP_036012290.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X3

Conserved Domains (2) summary

cd02659
Location:1892 → 2241

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam12030
Location:2359 → 2692

DUF3517; Domain of unknown function (DUF3517)
XM_030245632.2 → XP_030101492.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X6

Conserved Domains (1) summary

cd02659
Location:1731 → 2080

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_030245633.2 → XP_030101493.1 ubiquitin carboxyl-terminal hydrolase 34 isoform X7

Conserved Domains (1) summary

cd02659
Location:1719 → 2068

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...