1NBF,1NB8


Conserved Protein Domain Family
peptidase_C19C

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cd02659: peptidase_C19C 
Click on image for an interactive view with Cn3D
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Statistics
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PSSM-Id: 239124
View PSSM: cd02659
Aligned: 39 rows
Threshold Bit Score: 378.524
Threshold Setting Gi: 19173018
Created: 22-Apr-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Active Site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Active Site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #    #                                                                    
1NBF_A         5 GYVGLKNQGATCYMNSLLQTLFFTNQLRkavymm---------------------------------------------- 38
gi 59803114   39 NLSGIRNQGGTCYLNSLLQTLHFTPEFRealfslgpee------------------------------------------ 76
gi 50750133  174 NLSGIKNQGGTCYLNSLLQTLLFTPEFRealfslgpee------------------------------------------ 211
gi 55249607  171 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 205
gi 19173018  109 GYVGLRNLGATCYINSLMQALFSIAKFRndv------------------------------------------------- 139
gi 3334400    53 GYVGLVNQAMTCYLNSLLQALFMTPEFRnalyr----------------------------------------------- 85
gi 47230431  104 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalynwe--------------------------------------------- 138
gi 50747728  171 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 205
gi 24431982   98 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 132
gi 54657339  224 GYVGIRNLGATCYMNSLLQSLYHIGRFRkavytiplnpnritsgsscsntpisretrpeltpmsacipkiddfgevtpqs 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1NBF_A        39 ---------------------------ptegdDSSKSVPLALQRVFYELQhsdkpvgtkklt----------ksfgwetl 81
gi 59803114   77 -----------------------lglfedkdkPDAKVRIIPLQLQRLFAQlllldqeaastad-------ltdsfgwtsn 126
gi 50750133  212 -----------------------lgtlddvgkPDAKVRIIPLQLQRLFAQlllldqqaasttd-------ltesfgwnsn 261
gi 55249607  206 --------------------------feeseeDPVSSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 250
gi 19173018  140 ------------------------------fgLEPRGRVLLLQKLFKEMQtgehpvdttdf-----------vvnniwvd 178
gi 3334400    86 ---------------------------wefdnDNEAKKSYQLQKLFLNLQtspkaavettdl---------trsfgwdst 129
gi 47230431  139 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 183
gi 50747728  206 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 250
gi 24431982  133 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 177
gi 54657339  304 issesnslaisllgeasedaiewtsnvakslfEYESDGIASLESIMSSNAcqdygqntgvvsgnvsgpgstiggncsasd 383
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1NBF_A        82 dsfMQHDVQELCRVLLDNVEnkmkg----------------------------------------tcveGTIPKLFRGKM 121
gi 59803114  127 eemRQHDVQELNRILFSALEtslvg----------------------------------------tsghDLIYRLYHGTI 166
gi 50750133  262 eemRQHDVQELNRILFSALEtslvg----------------------------------------tsghDLINRLYHGTV 301
gi 55249607  251 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINQLYQGKL 290
gi 19173018  179 dvhVHQDIHEFSKVFFDSLEkds-------------------------------------------krkDVIEDMIQGEL 215
gi 3334400   130 eawQQHDIQELCRVMFDALEhkfkn----------------------------------------tkqaNLISNLYEGKM 169
gi 47230431  184 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------tvqaDLINQLYQGKL 223
gi 50747728  251 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINQLYQGKL 290
gi 24431982  178 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINELYQGKL 217
gi 54657339  384 agnDQTKISSALQTLFYELQtcsepvncrelmrsfgwdasdaftqhdaqelnrllcdrleeemkntavdGSIKALFEGEY 463
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1NBF_A       122 VSYiqckevdyrsdrreDYYDIQLSIKgk--------kNIFESFVDYVAVEQLDGDNKYDAGEhglq--eaeKGVKFLTL 191
gi 59803114  167 VNQivckec--knvserQEDFLDLTVAvkn------vsGLEDALWNMYVEEEVFDCDNLYHCGtcdrlvkaaKSAKLRKL 238
gi 50750133  302 VNQivckec--kniserQEDFLDLTVAvkg------vaGLEEALWNMYVEEEYFENENLYRCGacdklveasKSAKLHKL 373
gi 55249607  291 KDYvkclec--gyeswrIDTFLDIPLVirpygsntafgSMEEALHAFIQPETLDGPNQYFCERckrk-cdarKGLKFLHF 367
gi 19173018  216 VTYingkcg---cvrriKEKFQDIQVEirdffnnklssNLQESLKRYVKSEILDGNNRYNCEKhglv--dakKGVMFSSL 290
gi 3334400   170 NAYvkclgcn-tekndcEDTFLDIPLPvrpfgsssaygSIEEALRAFVQPETLDGNNQYLCEKckkk-cdahKGLHFKSF 247
gi 47230431  224 KDYvrclec--gyeswrIDTYLDIPLVirpfgasqaygSVEEALQAFIQPETLDGPNQYFCERcqkk-cdarKGLRFLHF 300
gi 50747728  291 KDYvrclec--gyegwrIDTYLDIPLVirpygsnqafaSVEEALHAFIQPEILDGPNQYFCERckkk-cdarKGLRFLHF 367
gi 24431982  218 KDYvrclec--gyegwrIDTYLDIPLVirpygssqafaSVEEALHAFIQPEILDGPNQYFCERckkk-cdarKGLRFLHF 294
gi 54657339  464 ENYiecldv--dctsrrRENFYDIQVDveg------vkSLEESLQRFVEEEILDGENLYEAEGfgkq--rakKGVRFQRF 533
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1NBF_A       192 PPVLHLQLMRFMYDPQtdqniKINDRFEFPEQLPLDEFLqkt-------------------------------------- 233
gi 59803114  239 PPFLTVSLLRFNFDFVkceryKETSCYTFPLRINLKPFCeqse------------------------------------- 281
gi 50750133  374 PPFLTISLLRFNFDFEkceryKETSCYTFPIQINLRPFCeqte------------------------------------- 416
gi 55249607  368 PYLLTLQLKRFDFDYTsmhriKLNDRMTFPDELDMSPFIdmedekspqtdsctdsgaenegschsdqms----------- 436
gi 19173018  291 PPVMFILLKRFNVDFEtgngyKINDYFEFPDSIDMLPFLdrdsk------------------------------------ 334
gi 3334400   248 PYILTLHLKRFDFDYQtmhriKLNDRVTFPQTLNLNTFInrsgnsgeqnsqlngtvddcstadsgsameddnlssgvvtt 327
gi 47230431  301 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSPFIdvedekspqtesctdsgaenegschsdqm------------ 368
gi 50747728  368 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSIFIdvedekspqtesctdsgaenegschsdqmsn---------- 437
gi 24431982  295 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSTFIdvedekspqtesctdsgaenegschsdqmsn---------- 364
gi 54657339  534 PPVVQFHLKRFQFNIQsmdmvKLNDYFTFPEKLDLSSFVnhnnkget--------------------------------- 580
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           #                  #         
1NBF_A       234 ----------------------------dpkDPANYILHAVLVHSGDnhGGHYVVYLNpkg-dgkWCKFDDDVVSRCTKe 284
gi 59803114  282 ----------------------------lddLEYIYDLFSVIIHKGGcyGGHYHVYIKdvd-hlgNWQFQEEKSKPDVNl 332
gi 50750133  417 ----------------------------mddSEYMYELFSVIIHKGGcyGGHYHVYIRdvdelgnWQLQEDEDRLIEDQp 468
gi 55249607  437 -ndfstddavdegicletnsnieklnksvaeKNSLYELFSVMVHSGSaaGGHYYACIKsfa-dgqWYSFNDQHVSRITQe 514
gi 19173018  335 ---------------------------rkeeSDATYDLYSVIVHRGDhdEGHFYAYLKin---grWLKFNDTVVTEAGEm 384
gi 3334400   328 asssqhendlndedegidmssstsksakqgsGPYLYELFAIMIHSGSasGGHYYAYIKdfd-nneWFCFNDQNVTSITQe 406
gi 47230431  369 --sndfstddcvdegicldstnnadrmlkpkSLLTFELFSVMVHSGSaaGGHYYAHIKsfs-dgqWYSFNDQHVSKITQe 445
gi 50747728  438 -dfsnddgvdegiclesnsaaeriakvgsekNSLLYELFSVMVHSGSaaGGHYYACIKsfs-ddqWYSFNDQHVSKITQe 515
gi 24431982  365 -dfsnddgvdegicletnsgtekisksglekNSLIYELFSVMAHSGSaaGGHYYACIKsfs-deqWYSFDDQHVSRITQe 442
gi 54657339  581 ------------------------dtgniveGTEKYILHTVVIHQGDvhSGHYYAYIRpkp-dsdWFRFDDEKVTLVSSs 635
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                                        
1NBF_A       285 ea--------------------iehNYGGHDddlsv------------rhctNAYMLVYIRESK 316
gi 59803114  333 ------------------------kDLQSEEeidh-------------plmiLKAILLEENNLI 359
gi 50750133  469 srdsentketenplavlkgilseeeCKQIPVdqlgqkfl-----ekikvswnKKYRKQYGALRK 527
gi 55249607  515 di--------------------kktYGGATGnrgyyss--------afasstNAYMLMYRLKNP 550
gi 19173018  385 ea--------------------lehNFGGRHpykdr------------irdhSGYYLIYLRKSM 416
gi 3334400   407 di---------------------qrSFGGPNgsyyss---------aytsstNAYMLMYRQVDA 440
gi 47230431  446 di--------------------rktYGGSSGsrgyyss--------afasstNAYMLIYRLKDP 481
gi 50747728  516 di--------------------kktYGGSSGsrgyyss--------afasstNAYMLIYRLKDP 551
gi 24431982  443 di--------------------kktHGGSSGsrgyyss--------afasstNAYMLIYRLKDP 478
gi 54657339  636 ta--------------------iedNFGGHEyevwdylgnpesdipkrskthSAYILVYVREDQ 679

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