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DCAF1 DDB1 and CUL4 associated factor 1 [ Homo sapiens (human) ]

Gene ID: 9730, updated on 23-May-2018
Official Symbol
DCAF1provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 1provided by HGNC
Primary source
HGNC:HGNC:30911
See related
Ensembl:ENSG00000145041 MIM:617259; Vega:OTTHUMG00000156895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP; VPRBP
Expression
Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues See more
Orthologs
See DCAF1 in Genome Data Viewer
Location:
3p21.2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (51394261..51505620, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51433298..51534018, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 3 Neighboring gene ST13, Hsp70 interacting protein pseudogene 14 Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte derived neurotrophic factor Neighboring gene uncharacterized LOC105377085 Neighboring gene RAD54 like 2 Neighboring gene RNA, U6atac small nuclear 29, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
HIV-1 Vpr downregulates HLTF in a DCAF1-dependent manner in HeLa, Jurkat T and primary T cells and primary macrophages as shown through DCAF1 siRNA knockdown PubMed
Knockdown of Vpr (HIV-1) binding protein (VPRBP) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation PubMed
env VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
Envelope surface glycoprotein gp160, precursor env DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
Envelope transmembrane glycoprotein gp41 env Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation PubMed
env VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
Pr55(Gag) gag DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells PubMed
Vpr vpr Vpr-dependent HIV-1 spread from MDMs to CD4+ T lymphocytes requires VPRBP (DCAF1) PubMed
vpr Vpr cooperates with VPRBP (DCAF1) to increase T lymphocyte HIV-1 infection by counteracting type I interferon inducible restriction of Env-dependent viral synapse formation between MDM and T cells PubMed
vpr HIV-1 Vpr binds DCAF1; Vpr E25,L26 and a2 E29 form a small pocket for DCAF1 W1156 binding (the N-terminal tail of Vpr wraps around the propeller, following small groove between two blades) PubMed
vpr HIV-1 Vpr binds DCAF1; residues R62, Q65 and R73 on a3 of Vpr form hydrogen bonds with E1088, S1136 and T1139 of DCAF1, respectively. Vpr F69 inserts in a small hydrophobic pocket formed by DCAF1 A1137, F1330 and F1355 PubMed
vpr DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env gp160 (gp120/gp41) expression in MDM cells PubMed
vpr Residues N1135 and W1156 in DCAF1 are required for its binding to the SIVmac Vpx Q76 residue but not with HIV-1 Vpr PubMed
vpr The minimal domain (residues 1041-1393) of DCAF1, which contains the motifs required for proper recruitment of both Vpr and DDB1, is not sufficient to support Vpr-mediated G2 arrest activity PubMed
vpr The two WD-40 motifs (residues 1041-1393) in the C-terminal region of DCAF1 form a complex with HIV-1 Vpr and DDB1. The double mutant DCAF1 R1247/1283A completely abolishes its ability to bind both Vpr and DDB1 PubMed
vpr The interaction of HIV-1 Vpr with the EDVP E3 ligase complex (EDD, DDB1, and VPRBP) promotes Vpr-mediated downregulation of TERT protein PubMed
vpr HIV-1 Vpr directly interacts with the C-terminal SLX1 binding domain of SLX4 and recruits VPRBP to the SSE regulator complex SLX4 PubMed
vpr Co-immunoprecipitation and glycerol-gradient sedimentation demonstrate that HIV-1 Vpr, VPRBP, DDB1, SLX4, MUS81, EME1, ERCC1, and ERCC4 form a complex PubMed
vpr HIV-1 Vpr-mediated UNG2 degradation and constitutive UNG2 turnover are dependent on DCAF1 or DDB1 but not on CUL4a or CUL4B in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells PubMed
vpr HIV-1 Vpr complexes with DCAF1, DDB1, CUL4A, CUL4B, and UNG2 proteins in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells PubMed
vpr Mutation of Trp18, Gln65, and His71 residues in HIV-1 Vpr abrogates DDB1-DCAF1 binding and Vpr-induced cell cycle arrest PubMed
vpr VPRBP is required for HIV-1 Vpr-mediated activation of the SLX4 complex and modulation of MUS81 levels. The interaction between Vpr and VPRBP is involved in MUS81 ubiquitination PubMed
vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
vpr HIV-1 Vpr induces the degradation of ZIP/sZIP through the DCAF1 ubiquitin ligase, while VprQ65R mutant impairs the Vpr-induced degradation of ZIP/sZIP PubMed
vpr HIV-1 Vpr co-localizes with the Cul4A ubiquitin ligase complex (Cul4A, DCAF1, and DDB1) in the cellular chromatin compartment PubMed
vpr HIV-1 Vpr induces the degradation of APOBEC3G through VprBP binding and participation of the proteasome, leading to a reduction in APOBEC3G encapsidation into virions PubMed
vpr The interaction of HIV-1 Vpr with VprBP enhances HIV-1 infection in monocyte-derived dendritic cells PubMed
vpr HIV-1 Vpr significantly downregulates expression level of MFN2 in the mitochondria via VprBP-DDB1-CUL4A ubiquitin ligase in a proteasome-dependent manner PubMed
vpr Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex PubMed
vpr W54R/S79A Vpr mutant impairs to interact with UNG2, but is still able to recruit DCAF1. Three G2 arrest-defective Vpr mutants, Q65R, K27M, and S79A, can interact with DCAF1 PubMed
vpr A highly conserved 18WxxxxFxxFxxxAFxH33 motif of the HIV-1 Vpr binds to DCAF1, leading to Vpr-induced G2 arrest. Vpr mutants L22S/L23S and V30S/V31S impair the ability to induce G2 arrest PubMed
vpr HIV-1 Vpr binds DCAF1 and activates the DNA damage response in renal tubule epithelial cells, in which gamma H2AX-positive nuclei are abundant compared to the control PubMed
vpr DCAF1 interacts with DDB1 as well as the Vpr-UNG2 complex, which leads to polyubiquitination of UNG2 via Vpr PubMed
vpr Recruitment of a catalytically active CRL4A (VPRBP) complex is required to observe HIV-1 Vpr-interacting unknown cellular ubiquitinated proteins. Phosphorylation of H2AX requires Vpr-induced K48 residue polyubiquitination PubMed
vpr HIV-1 Vpr forms nuclear foci containing VPRBP and partially co-localizes with DNA repair foci components 53BP1 and phosphorylated RPA32 PubMed
vpr HIV-1 Vpr(Q65R) mutant fails to bind DDB1 and VprBP, and also fails to induce G2 arrest PubMed
vpr The interaction between Vpr and the Cul4A-DDB1-VprBP complex is required for the induction of G2 arrest PubMed
vpr HIV-1 Vpr binds a ternary complex composed of DDB1, DDA1, and VprBP, and modulates the interaction between the DDB1-DDA1-VprBP complex and other factors PubMed
vpr The leucine/isoleucine-rich domain of HIV-1 Vpr (amino acids 60-81) mediates binding of Vpr to the C-terminal half of VprBP (amino acids 636-1507), resulting in the cytoplasmic retention of Vpr PubMed

Go to the HIV-1, Human Interaction Database

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0800, MGC102804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone kinase activity (H2A-T120 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone kinase activity (H2A-T120 specific) IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
V(D)J recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
cell competition in a multicellular organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H2A-T120 phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H2A-T120 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DDB1- and CUL4-associated factor 1
Names
HIV-1 Vpr-binding protein
Vpr (HIV-1) binding protein
Vpr-binding protein
protein VPRBP
serine/threonine-protein kinase VPRBP
vpr-interacting protein
NP_001165375.1
NP_001336097.1
NP_001336098.1
NP_001336099.1
NP_001336100.1
NP_055518.1
XP_005276810.1
XP_005276812.1
XP_011532575.1
XP_011532577.1
XP_016863035.1
XP_016863036.1
XP_016863038.1
XP_016863039.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171904.1NP_001165375.1  DDB1- and CUL4-associated factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001165375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR and uses and alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AB018343, BC110371, BP222559, CR986856
    Consensus CDS
    CCDS74944.1
    UniProtKB/Swiss-Prot
    Q9Y4B6
    Related
    ENSP00000421724.2, ENST00000504652.5
    Conserved Domains (3) summary
    COG2319
    Location:10671370
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:10961132
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10921310
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001349168.1NP_001336097.1  DDB1- and CUL4-associated factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC092037, AC233756
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  3. NM_001349169.1NP_001336098.1  DDB1- and CUL4-associated factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC092037, AC233756
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  4. NM_001349170.1NP_001336099.1  DDB1- and CUL4-associated factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC092037, AC233756
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  5. NM_001349171.1NP_001336100.1  DDB1- and CUL4-associated factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTR and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC092037, AC233756
    Conserved Domains (3) summary
    sd00039
    Location:10151051
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10111229
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:806965
    Retinal; Retinal protein
  6. NM_014703.2NP_055518.1  DDB1- and CUL4-associated factor 1 isoform 1

    See identical proteins and their annotated locations for NP_055518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AB018343, CR986856
    Consensus CDS
    CCDS74943.1
    UniProtKB/Swiss-Prot
    Q9Y4B6
    Related
    ENSP00000393183.2, OTTHUMP00000210952, ENST00000423656.5, OTTHUMT00000346488
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein

RNA

  1. NR_146065.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092037, AC233756

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    51394261..51505620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007549.2XP_016863038.1  DDB1- and CUL4-associated factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  2. XM_017007550.2XP_016863039.1  DDB1- and CUL4-associated factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  3. XM_017007547.2XP_016863036.1  DDB1- and CUL4-associated factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  4. XM_011534275.3XP_011532577.1  DDB1- and CUL4-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011532577.1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  5. XM_011534273.3XP_011532575.1  DDB1- and CUL4-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011532575.1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  6. XM_005276755.5XP_005276812.1  DDB1- and CUL4-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005276812.1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  7. XM_017007546.2XP_016863035.1  DDB1- and CUL4-associated factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein
  8. XM_005276753.5XP_005276810.1  DDB1- and CUL4-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005276810.1

    UniProtKB/Swiss-Prot
    Q9Y4B6
    Conserved Domains (3) summary
    sd00039
    Location:10971133
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:10931311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl25836
    Location:8881047
    Retinal; Retinal protein

RNA

  1. XR_001740385.2 RNA Sequence

  2. XR_001740387.2 RNA Sequence

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