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Dcaf1 DDB1 and CUL4 associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 321006, updated on 12-May-2024

Summary

Official Symbol
Dcaf1provided by MGI
Official Full Name
DDB1 and CUL4 associated factor 1provided by MGI
Primary source
MGI:MGI:2445220
See related
Ensembl:ENSMUSG00000040325 AllianceGenome:MGI:2445220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vprbp; mKIAA0800; B930007L02Rik
Summary
Predicted to enable estrogen receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in B cell differentiation and V(D)J recombination. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of COP9 signalosome and Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DCAF1 (DDB1 and CUL4 associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.0), CNS E11.5 (RPKM 10.7) and 28 other tissues See more
Orthologs
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Genomic context

See Dcaf1 in Genome Data Viewer
Location:
9 F1; 9 57.98 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106691354..106758191)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106814169..106880992)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene predicted gene, 18542

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation
  • Transgenic (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H2AT120 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 1
Names
Vpr (HIV-1) binding protein
protein VPRBP
serine/threonine-protein kinase VPRBP
NP_001015507.1
NP_001360859.1
NP_001360860.1
XP_006511816.1
XP_006511817.1
XP_036010962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015507.3NP_001015507.1  DDB1- and CUL4-associated factor 1 isoform 3

    See identical proteins and their annotated locations for NP_001015507.1

    Status: VALIDATED

    Source sequence(s)
    AC147636
    Consensus CDS
    CCDS23485.1
    UniProtKB/Swiss-Prot
    Q80TR8
    Related
    ENSMUSP00000123865.2, ENSMUST00000159645.8
    Conserved Domains (2) summary
    sd00039
    Location:10961132
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10921310
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001373930.1NP_001360859.1  DDB1- and CUL4-associated factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC147636
    Consensus CDS
    CCDS90657.1
    UniProtKB/Swiss-Prot
    Q3UXD5, Q6P1E2, Q80TR8, Q8CDY3
    Related
    ENSMUSP00000060025.9, ENSMUST00000055009.15
    Conserved Domains (2) summary
    sd00039
    Location:10961132
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10921310
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001373931.1NP_001360860.1  DDB1- and CUL4-associated factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC147636
    Conserved Domains (2) summary
    sd00039
    Location:10431079
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10391257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106691354..106758191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511753.4XP_006511816.1  DDB1- and CUL4-associated factor 1 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:11061142
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11021320
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006511754.4XP_006511817.1  DDB1- and CUL4-associated factor 1 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:11061142
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:11021320
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_036155069.1XP_036010962.1  DDB1- and CUL4-associated factor 1 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:10961132
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10921310
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_379768.5 RNA Sequence

  2. XR_004935462.1 RNA Sequence

  3. XR_004935461.1 RNA Sequence