Format

Send to:

Choose Destination

CD79A CD79a molecule [ Homo sapiens (human) ]

Gene ID: 973, updated on 7-Jun-2020

Summary

Official Symbol
CD79Aprovided by HGNC
Official Full Name
CD79a moleculeprovided by HGNC
Primary source
HGNC:HGNC:1698
See related
Ensembl:ENSG00000105369 MIM:112205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGA; MB-1
Summary
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 171.0), spleen (RPKM 119.8) and 7 other tissues See more
Orthologs

Genomic context

See CD79A in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41877279..41881372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42381190..42385439)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LY6/PLAUR domain containing 4 Neighboring gene DMRT like family C2 Neighboring gene ribosomal protein S19 Neighboring gene microRNA 6797 Neighboring gene Rho guanine nucleotide exchange factor 1 Neighboring gene ETS repressor factor like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD79a molecule, immunoglobulin-associated alpha (CD79A) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
B cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
multivesicular body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
B-cell antigen receptor complex-associated protein alpha chain
Names
CD79a antigen (immunoglobulin-associated alpha)
CD79a molecule, immunoglobulin-associated alpha
MB-1 membrane glycoprotein
ig-alpha
membrane-bound immunoglobulin-associated protein
surface IgM-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009619.1 RefSeqGene

    Range
    5001..9250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_42

mRNA and Protein(s)

  1. NM_001783.4NP_001774.1  B-cell antigen receptor complex-associated protein alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001774.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC243967
    Consensus CDS
    CCDS12589.1
    UniProtKB/Swiss-Prot
    P11912
    Related
    ENSP00000221972.3, ENST00000221972.8
    Conserved Domains (2) summary
    smart00077
    Location:185205
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:39125
    IG_like; Immunoglobulin like
  2. NM_021601.4NP_067612.1  B-cell antigen receptor complex-associated protein alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_067612.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC243967, X83540
    Consensus CDS
    CCDS46088.1
    UniProtKB/Swiss-Prot
    P11912
    Related
    ENSP00000400605.1, ENST00000444740.2
    Conserved Domains (2) summary
    smart00077
    Location:147167
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:3968
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41877279..41881372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center