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RAB11FIP3 RAB11 family interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 9727, updated on 8-Jul-2021

Summary

Official Symbol
RAB11FIP3provided by HGNC
Official Full Name
RAB11 family interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:17224
See related
Ensembl:ENSG00000090565 MIM:608738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CART1; FIP3-Rab11; Rab11-FIP3
Summary
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in kidney (RPKM 33.4), brain (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

See RAB11FIP3 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (425621..523011)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (475649..573011)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371036 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene long intergenic non-protein coding RNA 235 Neighboring gene calpain 15 Neighboring gene microRNA 5587

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0665, PAC196A12.1, MU-MB-17.148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein light intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to cilium IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rab11 family-interacting protein 3
Names
EF hands-containing Rab-interacting protein
MU-MB-17.148
RAB11 family interacting protein 3 (class II)
arfophilin-1
cytoplasmic adaptor for RAR and TR
eferin
NP_001135744.2
NP_001357330.1
NP_055515.1
XP_005255771.1
XP_005255772.1
XP_005255774.1
XP_005255775.1
XP_011521066.1
XP_011521067.1
XP_016879396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142272.2NP_001135744.2  rab11 family-interacting protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL049542, Z98882
    Consensus CDS
    CCDS45364.1
    Related
    ENSP00000415919.1, ENST00000450428.5
    Conserved Domains (2) summary
    TIGR02168
    Location:160432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09457
    Location:406446
    RBD-FIP; FIP domain
  2. NM_001370401.1NP_001357330.1  rab11 family-interacting protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL023881, AL049542, Z98882
    Related
    ENSP00000399644.1, ENST00000434585.5
    Conserved Domains (4) summary
    PRK07764
    Location:3223
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    TIGR02168
    Location:515787
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09457
    Location:761801
    RBD-FIP; FIP domain
    pfam13499
    Location:206264
    EF-hand_7; EF-hand domain pair
  3. NM_014700.4NP_055515.1  rab11 family-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL023881, BC051360, Z98882
    Consensus CDS
    CCDS32351.1
    UniProtKB/Swiss-Prot
    O75154
    Related
    ENSP00000262305.4, ENST00000262305.9
    Conserved Domains (8) summary
    COG1842
    Location:459674
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:716756
    RBD-FIP; FIP domain
    pfam05700
    Location:486589
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:540631
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam15068
    Location:80140
    FAM101; FAM101 family
    pfam16034
    Location:577691
    JAKMIP_CC3; JAKMIP CC3 domain
    cl08302
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    425621..523011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023907.1XP_016879396.1  rab11 family-interacting protein 3 isoform X2

  2. XM_005255717.3XP_005255774.1  rab11 family-interacting protein 3 isoform X5

    See identical proteins and their annotated locations for XP_005255774.1

    Conserved Domains (3) summary
    cd00051
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam16214
    Location:85220
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  3. XM_005255718.3XP_005255775.1  rab11 family-interacting protein 3 isoform X7

    See identical proteins and their annotated locations for XP_005255775.1

    Conserved Domains (3) summary
    cd00051
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam16214
    Location:85220
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  4. XM_011522765.2XP_011521067.1  rab11 family-interacting protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011521067.1

    Conserved Domains (4) summary
    COG1842
    Location:162377
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:419459
    RBD-FIP; FIP domain
    pfam05700
    Location:189292
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:243334
    Tho2; Transcription factor/nuclear export subunit protein 2
  5. XM_005255715.5XP_005255772.1  rab11 family-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_005255772.1

    UniProtKB/Swiss-Prot
    O75154
    Conserved Domains (4) summary
    COG1842
    Location:194409
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:451491
    RBD-FIP; FIP domain
    pfam05700
    Location:221324
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:275366
    Tho2; Transcription factor/nuclear export subunit protein 2
  6. XM_005255714.1XP_005255771.1  rab11 family-interacting protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005255771.1

    Conserved Domains (5) summary
    COG1842
    Location:208423
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:465505
    RBD-FIP; FIP domain
    pfam05700
    Location:235338
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:289380
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam16034
    Location:326440
    JAKMIP_CC3; JAKMIP CC3 domain
  7. XM_011522764.2XP_011521066.1  rab11 family-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011521066.1

    UniProtKB/Swiss-Prot
    O75154
    Conserved Domains (4) summary
    COG1842
    Location:194409
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:451491
    RBD-FIP; FIP domain
    pfam05700
    Location:221324
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:275366
    Tho2; Transcription factor/nuclear export subunit protein 2

RNA

  1. XR_932981.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187610.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    24795..125679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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