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RAB11FIP3 RAB11 family interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 9727, updated on 7-Dec-2018

Summary

Official Symbol
RAB11FIP3provided by HGNC
Official Full Name
RAB11 family interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:17224
See related
Ensembl:ENSG00000090565 MIM:608738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CART1; Rab11-FIP3
Summary
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in kidney (RPKM 33.4), brain (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See RAB11FIP3 in Genome Data Viewer
Location:
16p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (425621..522485)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (475649..572485)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371036 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene long intergenic non-protein coding RNA 235 Neighboring gene calpain 15 Neighboring gene microRNA 5587

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 downstream pathway, organism-specific biosystem
    Arf6 downstream pathway
  • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
    Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
    VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ADP-ribosylation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rab GTPase binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
dynein light intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic recycling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to cilium IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rab11 family-interacting protein 3
Names
EF hands-containing Rab-interacting protein
FIP3-Rab11
MU-MB-17.148
PAC196A12.1
RAB11 family interacting protein 3 (class II)
arfophilin-1
cytoplasmic adaptor for RAR and TR
eferin
NP_001135744.1
NP_055515.1
XP_005255770.1
XP_005255771.1
XP_005255772.1
XP_005255774.1
XP_005255775.1
XP_011521066.1
XP_011521067.1
XP_016879396.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142272.1NP_001135744.1  rab11 family-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001135744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK293644, BC051360, DC395000, DC404361
    Consensus CDS
    CCDS45364.1
    UniProtKB/Swiss-Prot
    O75154
    Related
    ENSP00000415919.1, ENST00000450428.5
    Conserved Domains (2) summary
    pfam09457
    Location:420460
    RBD-FIP; FIP domain
    cl25732
    Location:174446
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_014700.4NP_055515.1  rab11 family-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL023881, BC051360, Z98882
    Consensus CDS
    CCDS32351.1
    UniProtKB/Swiss-Prot
    O75154
    Related
    ENSP00000262305.4, ENST00000262305.8
    Conserved Domains (8) summary
    COG1842
    Location:459674
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:716756
    RBD-FIP; FIP domain
    pfam05700
    Location:486589
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:540631
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam15068
    Location:80140
    FAM101; FAM101 family
    pfam16034
    Location:577691
    JAKMIP_CC3; JAKMIP CC3 domain
    cl08302
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    425621..522485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023907.1XP_016879396.1  rab11 family-interacting protein 3 isoform X2

  2. XM_005255717.3XP_005255774.1  rab11 family-interacting protein 3 isoform X5

    See identical proteins and their annotated locations for XP_005255774.1

    Conserved Domains (3) summary
    cd00051
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam16214
    Location:85220
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  3. XM_005255718.3XP_005255775.1  rab11 family-interacting protein 3 isoform X7

    See identical proteins and their annotated locations for XP_005255775.1

    Conserved Domains (3) summary
    cd00051
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam16214
    Location:85220
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  4. XM_005255713.3XP_005255770.1  rab11 family-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005255770.1

    UniProtKB/Swiss-Prot
    O75154
    Related
    ENSP00000399644.1, ENST00000434585.5
    Conserved Domains (7) summary
    COG1842
    Location:504719
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:761801
    RBD-FIP; FIP domain
    pfam05700
    Location:531634
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam13499
    Location:207263
    EF-hand_7; EF-hand domain pair
    pfam15068
    Location:80140
    FAM101; FAM101 family
    pfam16034
    Location:622736
    JAKMIP_CC3; JAKMIP CC3 domain
    cl08302
    Location:206264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_011522765.2XP_011521067.1  rab11 family-interacting protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011521067.1

    Conserved Domains (4) summary
    COG1842
    Location:162377
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:419459
    RBD-FIP; FIP domain
    pfam05700
    Location:189292
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:243334
    Tho2; Transcription factor/nuclear export subunit protein 2
  6. XM_005255715.5XP_005255772.1  rab11 family-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_005255772.1

    UniProtKB/Swiss-Prot
    O75154
    Conserved Domains (4) summary
    COG1842
    Location:194409
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:451491
    RBD-FIP; FIP domain
    pfam05700
    Location:221324
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:275366
    Tho2; Transcription factor/nuclear export subunit protein 2
  7. XM_005255714.1XP_005255771.1  rab11 family-interacting protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005255771.1

    Conserved Domains (5) summary
    COG1842
    Location:208423
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:465505
    RBD-FIP; FIP domain
    pfam05700
    Location:235338
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:289380
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam16034
    Location:326440
    JAKMIP_CC3; JAKMIP CC3 domain
  8. XM_011522764.2XP_011521066.1  rab11 family-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011521066.1

    UniProtKB/Swiss-Prot
    O75154
    Conserved Domains (4) summary
    COG1842
    Location:194409
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam09457
    Location:451491
    RBD-FIP; FIP domain
    pfam05700
    Location:221324
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    pfam11262
    Location:275366
    Tho2; Transcription factor/nuclear export subunit protein 2

RNA

  1. XR_932981.2 RNA Sequence

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187610.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    24814..125149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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