Format

Send to:

Choose Destination

FEZ1 fasciculation and elongation protein zeta 1 [ Homo sapiens (human) ]

Gene ID: 9638, updated on 3-Jun-2018
Official Symbol
FEZ1provided by HGNC
Official Full Name
fasciculation and elongation protein zeta 1provided by HGNC
Primary source
HGNC:HGNC:3659
See related
Ensembl:ENSG00000149557 MIM:604825; Vega:OTTHUMG00000165886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC-76
Summary
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 74.3), urinary bladder (RPKM 9.7) and 4 other tissues See more
Orthologs
See FEZ1 in Genome Data Viewer
Location:
11q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (125445745..125496310, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125315641..125366206, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PBX/knotted 1 homeobox 2 Neighboring gene uncharacterized LOC105369549 Neighboring gene RNA, U6 small nuclear 321, pseudogene Neighboring gene putative uncharacterized protein MGC39545 Neighboring gene RNA, U6 small nuclear 1156, pseudogene Neighboring gene STT3A antisense RNA 1 Neighboring gene EI24, autophagy associated transmembrane protein Neighboring gene STT3A, catalytic subunit of the oligosaccharyltransferase complex

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
RNAi-mediated FEZ1 depletion inhibits early infection, with virus particles exhibiting bi-directional motility but no net movement to the nucleus PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag The ability of exogenously expressed FEZ1 binding to kinesin-1 to promote early HIV-1 infection, leading to the movement of HIV-1 CA core to the nucleus PubMed
gag HIV-1 CA binds to FEZ1 to facilitate the core complex for inward movement to the nucleus PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of mitochondrion localization IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
mitochondrion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of anterograde axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fasciculation and elongation protein zeta-1
Names
zygin I
zygin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005103.4NP_005094.1  fasciculation and elongation protein zeta-1 isoform 1

    See identical proteins and their annotated locations for NP_005094.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the full-length isoform (1), which has a longer C-terminal end compared to isoform 2.
    Source sequence(s)
    BC009545, BM663785, DA697171
    Consensus CDS
    CCDS31716.1
    UniProtKB/Swiss-Prot
    Q99689
    Related
    ENSP00000278919.3, OTTHUMP00000231425, ENST00000278919.7, OTTHUMT00000386875
    Conserved Domains (1) summary
    pfam07763
    Location:58297
    FEZ; FEZ-like protein
  2. NM_022549.3NP_072043.1  fasciculation and elongation protein zeta-1 isoform 2

    See identical proteins and their annotated locations for NP_072043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes a protein isoform (2) that is truncated at the C-terminal end compared to isoform 1.
    Source sequence(s)
    AP000708, CN310685, DA697171, U60062
    Consensus CDS
    CCDS44758.1
    UniProtKB/Swiss-Prot
    Q99689
    Related
    ENSP00000393425.2, OTTHUMP00000231427, ENST00000366139.3, OTTHUMT00000386885
    Conserved Domains (1) summary
    pfam07763
    Location:5892
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    125445745..125496310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271735.2XP_005271792.1  fasciculation and elongation protein zeta-1 isoform X1

    See identical proteins and their annotated locations for XP_005271792.1

    UniProtKB/Swiss-Prot
    Q99689
    Conserved Domains (1) summary
    pfam07763
    Location:58297
    FEZ; FEZ-like protein
  2. XM_005271734.2XP_005271791.1  fasciculation and elongation protein zeta-1 isoform X1

    See identical proteins and their annotated locations for XP_005271791.1

    UniProtKB/Swiss-Prot
    Q99689
    Conserved Domains (1) summary
    pfam07763
    Location:58297
    FEZ; FEZ-like protein
Support Center