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RGS6 regulator of G protein signaling 6 [ Homo sapiens (human) ]

Gene ID: 9628, updated on 2-Oct-2018

Summary

Official Symbol
RGS6provided by HGNC
Official Full Name
regulator of G protein signaling 6provided by HGNC
Primary source
HGNC:HGNC:10002
See related
Ensembl:ENSG00000182732 MIM:603894; Vega:OTTHUMG00000171340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAP; S914; HA117
Summary
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See RGS6 in Genome Data Viewer
Location:
14q24.2
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (71867397..72632478)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (72398817..73033238)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene signal induced proliferation associated 1 like 1 Neighboring gene RNA, 7SL, cytoplasmic 683, pseudogene Neighboring gene uncharacterized LOC145474 Neighboring gene uncharacterized LOC105370559 Neighboring gene microRNA 7843 Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC107984711 Neighboring gene ribosomal protein L36 pseudogene 3 Neighboring gene DDB1 and CUL4 associated factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystem (from REACTOME)
    Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystemThe chaperonin complex TRiC/CCT is needed for the proper folding of all five G-protein beta subunits (Wells et al. 2006). TRiC/CCT cooperates with the phosducin-like protein PDCL (commonly known as P...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43552, MGC142132, DKFZp313G1241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 6
Names
regulator of G-protein signalling 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029236.1 RefSeqGene

    Range
    5001..639422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204416.2NP_001191345.1  regulator of G-protein signaling 6 isoform 1

    See identical proteins and their annotated locations for NP_001191345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as RGS6Lalpha1). Variants 1 and 10 encode the same isoform.
    Source sequence(s)
    AC004828, AF107619, AF156932, BC104877, BX096120, BX537512, DC317315, DC343081
    Consensus CDS
    CCDS55924.1
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Related
    ENSP00000451855.1, OTTHUMP00000245843, ENST00000556437.5, OTTHUMT00000413035
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. NM_001204417.2NP_001191346.1  regulator of G-protein signaling 6 isoform 3

    See identical proteins and their annotated locations for NP_001191346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (3, also known as RGS6Lbeta1) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF073921, BC104877, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Related
    ENSP00000384612.4, ENST00000407322.8
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. NM_001204418.2NP_001191347.1  regulator of G-protein signaling 6 isoform 4

    See identical proteins and their annotated locations for NP_001191347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing the penultimate coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (4, also known as RGS6Lbeta2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF073921, BC104877, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  4. NM_001204419.2NP_001191348.1  regulator of G-protein signaling 6 isoform 5

    See identical proteins and their annotated locations for NP_001191348.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5, also known as RGS6Lalpha1(-GGL)) missing a segment of the GGL domain, compared to isoform 1.
    Source sequence(s)
    AC004828, AF107619, AF156932, BC104877, BX096120, BX537512, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Related
    ENSP00000341199.7, ENST00000343854.10
    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  5. NM_001204420.2NP_001191349.1  regulator of G-protein signaling 6 isoform 6

    See identical proteins and their annotated locations for NP_001191349.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks 2 non-consecutive in-frame coding exons compared to variant 1, resulting in a shorter isoform (6, also known as RGS6Lalpha2(-GGL)) missing 2 internal protein segments, compared to isoform 1.
    Source sequence(s)
    AC004828, AF156932, BC104877, BX096120, BX537512, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  6. NM_001204421.2NP_001191350.1  regulator of G-protein signaling 6 isoform 7

    See identical proteins and their annotated locations for NP_001191350.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is missing an in-frame coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (7, also known as RGS6Lbeta1(-GGL)) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF073921, BC104877, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  7. NM_001204422.2NP_001191351.1  regulator of G-protein signaling 6 isoform 8

    See identical proteins and their annotated locations for NP_001191351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks 2 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (8, also known as RGS6Lbeta2(-GGL)) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF073921, BC104877, DC317315, DC343081
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  8. NM_001204423.1NP_001191352.1  regulator of G-protein signaling 6 isoform 9

    See identical proteins and their annotated locations for NP_001191352.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and is missing 2 non-consecutive exons compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (9) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC004828, AF156932, AK294895, BC104877, BX096120, BX537512
    Consensus CDS
    CCDS73655.1
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    B7Z2N1, Q2M3K2
    Related
    ENSP00000383953.3, ENST00000402788.6
    Conserved Domains (3) summary
    smart00224
    Location:223284
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:293417
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:184
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  9. NM_001204424.1NP_001191353.1  regulator of G-protein signaling 6 isoform 1

    See identical proteins and their annotated locations for NP_001191353.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same isoform (1).
    Source sequence(s)
    AC004828, AF107619, AF156932, AK294486, BC104877, BX096120, BX537512
    Consensus CDS
    CCDS55924.1
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    B7Z2A0, Q2M3K2
    Related
    ENSP00000451030.1, OTTHUMP00000245839, ENST00000553525.5, OTTHUMT00000413031
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  10. NM_004296.6NP_004287.3  regulator of G-protein signaling 6 isoform 2

    See identical proteins and their annotated locations for NP_004287.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the in-frame penultimate coding exon compared to variant 1. This results in a shorter isoform (2, also known as RGS6Lalpha2), missing an 18 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC004828, AF156932, BC104877, BX096120, BX537512, DC317315, DC343081
    Consensus CDS
    CCDS9808.1
    UniProtKB/Swiss-Prot
    P49758
    UniProtKB/TrEMBL
    Q2M3K2
    Related
    ENSP00000452331.1, OTTHUMP00000245841, ENST00000553530.5, OTTHUMT00000413033
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RNA

  1. NR_135235.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site and contains an alternate internal exon in the 3' region resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004828, AF156932, BC143699, BX096120, BX537512, DA386861, DC317315

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    71867397..72632478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449761.1XP_024305529.1  regulator of G-protein signaling 6 isoform X1

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. XM_024449766.1XP_024305534.1  regulator of G-protein signaling 6 isoform X6

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. XM_024449773.1XP_024305541.1  regulator of G-protein signaling 6 isoform X16

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  4. XM_017021825.2XP_016877314.1  regulator of G-protein signaling 6 isoform X13

  5. XM_017021822.2XP_016877311.1  regulator of G-protein signaling 6 isoform X8

  6. XM_017021827.2XP_016877316.1  regulator of G-protein signaling 6 isoform X15

  7. XM_024449767.1XP_024305535.1  regulator of G-protein signaling 6 isoform X9

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  8. XM_024449759.1XP_024305527.1  regulator of G-protein signaling 6 isoform X1

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  9. XM_024449762.1XP_024305530.1  regulator of G-protein signaling 6 isoform X2

    Conserved Domains (4) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl26247
    Location:417606
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  10. XM_024449775.1XP_024305543.1  regulator of G-protein signaling 6 isoform X20

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  11. XM_024449771.1XP_024305539.1  regulator of G-protein signaling 6 isoform X16

    Related
    ENSP00000450936.1, ENST00000555571.5
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  12. XM_017021820.2XP_016877309.1  regulator of G-protein signaling 6 isoform X3

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  13. XM_024449768.1XP_024305536.1  regulator of G-protein signaling 6 isoform X10

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  14. XM_024449776.1XP_024305544.1  regulator of G-protein signaling 6 isoform X23

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  15. XM_024449777.1XP_024305545.1  regulator of G-protein signaling 6 isoform X24

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  16. XM_024449770.1XP_024305538.1  regulator of G-protein signaling 6 isoform X12

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  17. XM_024449774.1XP_024305542.1  regulator of G-protein signaling 6 isoform X19

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  18. XM_017021830.2XP_016877319.1  regulator of G-protein signaling 6 isoform X20

    UniProtKB/Swiss-Prot
    P49758
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  19. XM_017021826.2XP_016877315.1  regulator of G-protein signaling 6 isoform X14

    UniProtKB/Swiss-Prot
    P49758
    Related
    ENSP00000384218.4, OTTHUMP00000245846, ENST00000406236.8
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  20. XM_017021828.2XP_016877317.1  regulator of G-protein signaling 6 isoform X18

  21. XM_017021832.2XP_016877321.1  regulator of G-protein signaling 6 isoform X22

    UniProtKB/Swiss-Prot
    P49758
    Related
    ENSP00000347699.6, OTTHUMP00000245844, ENST00000355512.10
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  22. XM_017021831.2XP_016877320.1  regulator of G-protein signaling 6 isoform X21

  23. XM_017021833.2XP_016877322.1  regulator of G-protein signaling 6 isoform X25

  24. XM_017021819.1XP_016877308.1  regulator of G-protein signaling 6 isoform X2

    Conserved Domains (4) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl26247
    Location:417606
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  25. XM_017021829.1XP_016877318.1  regulator of G-protein signaling 6 isoform X20

    UniProtKB/Swiss-Prot
    P49758
    Related
    ENSP00000450858.1, OTTHUMP00000245842, ENST00000554474.5, OTTHUMT00000413034
    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  26. XM_017021824.1XP_016877313.1  regulator of G-protein signaling 6 isoform X10

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  27. XM_024449760.1XP_024305528.1  regulator of G-protein signaling 6 isoform X1

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  28. XM_024449765.1XP_024305533.1  regulator of G-protein signaling 6 isoform X6

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  29. XM_024449769.1XP_024305537.1  regulator of G-protein signaling 6 isoform X11

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  30. XM_024449772.1XP_024305540.1  regulator of G-protein signaling 6 isoform X16

    Conserved Domains (3) summary
    smart00224
    Location:258319
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:328452
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  31. XM_024449778.1XP_024305546.1  regulator of G-protein signaling 6 isoform X24

    Conserved Domains (3) summary
    cd08737
    Location:291415
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:31119
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl00069
    Location:258285
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  32. XM_011537407.2XP_011535709.1  regulator of G-protein signaling 6 isoform X17

    Conserved Domains (2) summary
    smart00224
    Location:44105
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:114238
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
  33. XM_011537393.2XP_011535695.1  regulator of G-protein signaling 6 isoform X4

    Conserved Domains (2) summary
    smart00224
    Location:198259
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:268392
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
  34. XM_024449764.1XP_024305532.1  regulator of G-protein signaling 6 isoform X5

    Conserved Domains (3) summary
    smart00224
    Location:189250
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:259383
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:150
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  35. XM_024449763.1XP_024305531.1  regulator of G-protein signaling 6 isoform X5

    Conserved Domains (3) summary
    smart00224
    Location:189250
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:259383
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
    cd04450
    Location:150
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  36. XM_011537397.1XP_011535699.1  regulator of G-protein signaling 6 isoform X7

    See identical proteins and their annotated locations for XP_011535699.1

    Conserved Domains (2) summary
    smart00224
    Location:119180
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:189313
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
  37. XM_017021834.1XP_016877323.1  regulator of G-protein signaling 6 isoform X26

    UniProtKB/Swiss-Prot
    P49758
    Related
    ENSP00000451912.1, OTTHUMP00000245849, ENST00000554782.1, OTTHUMT00000413043
    Conserved Domains (2) summary
    smart00224
    Location:119180
    GGL; G protein gamma subunit-like motifs
    cd08737
    Location:189313
    RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

RNA

  1. XR_001750613.2 RNA Sequence

  2. XR_002957573.1 RNA Sequence

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