Rgs6 regulator of G-protein signaling 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs6provided by MGI
Official Full Name: regulator of G-protein signaling 6provided by MGI
Primary source: MGI:MGI:1354730
See related: Ensembl:ENSMUSG00000021219 AllianceGenome:MGI:1354730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]
Expression: Biased expression in cortex adult (RPKM 4.8), frontal lobe adult (RPKM 3.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 38.14 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (82663325..83208835)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (82616551..83162061)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway in Mice.
Title: RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway in Mice.
RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis.
Title: RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis.
Age-dependent nigral dopaminergic neurodegeneration and alpha-synuclein accumulation in RGS6-deficient mice.
Title: Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.
Title: GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.
RGS 6 mediated cardiac hypertrophy by directly interacting with apoptosis signal-regulating kinase 1, which further activates the P38-c- JUN N-terminal kinase 1/2 signaling pathway. Conclusions Based on our findings, RGS 6 aggravates cardiac hypertrophy, and the RGS 6-apoptosis signal-regulating kinase 1 pathway represents a potential therapeutic target to attenuate pressure overload-driven cardiac remodeling
Title: Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal-Regulating Kinase 1-P38/c-JUN N-Terminal Kinase 1/2 Signaling.
RGS6 and oxidized CaMKIIdelta together function as novel critical upstream modulators of Notch signaling required for normal cardiovascular development and embryo survival.
Title: Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca(2+)/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.
Data show that RGS6 loss impairs p53 activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.
Title: RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
The genetic loss of Rgs6 is associated with three phenotypes each individually associated with midbrain dopaminergic neuron neuron degeneration.
Title: Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
propose that inhibition of RGS6 might represent a viable means to reduce alcohol cravings and withdrawal in human patients, while simultaneously protecting the heart and liver from further damage upon relapse
Title: Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol.
RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis
Title: RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Mit176 (e-PCR), detects polymorphism
- UniSTS:126731

D12Mit227 (e-PCR), detects polymorphism
- UniSTS:126782

09.MMHAP61FRC9.seq (e-PCR)
- UniSTS:122986

D12Mit158 (e-PCR), detects polymorphism
- UniSTS:116400

40.MMHAP53FLF4.seq (e-PCR)
- UniSTS:124369

12.MMHAP36FLD3.seq (e-PCR)
- UniSTS:123117

Homology

Homologs of the Rgs6 gene: The Rgs6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 335 organisms have orthologs with human gene Rgs6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of G-protein signaling 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282061.3 → NP_001268990.1 regulator of G-protein signaling 6 isoform 2

See identical proteins and their annotated locations for NP_001268990.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. Variants 1, 2, 4 and 5 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787

Consensus CDS

CCDS79132.1

UniProtKB/Swiss-Prot

Q8BGI8, Q9Z2H2

Related

ENSMUSP00000139735.2, ENSMUST00000186458.7

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
NM_001310478.3 → NP_001297407.1 regulator of G-protein signaling 6 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes the longest isoform (1).

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787

Consensus CDS

CCDS79131.1

UniProtKB/Swiss-Prot

Q9Z2H2

UniProtKB/TrEMBL

A0A087WNZ9, A0A087WRN0, Q3UTM5

Related

ENSMUSP00000139566.2, ENSMUST00000185665.7

Conserved Domains (3) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001413651.1 → NP_001400580.1 regulator of G-protein signaling 6 isoform 2

Status: REVIEWED

Description

Transcript Variant: Variants 1, 2, 4 and 5 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787

UniProtKB/Swiss-Prot

Q8BGI8
NM_001413652.1 → NP_001400581.1 regulator of G-protein signaling 6 isoform 2

Status: REVIEWED

Description

Transcript Variant: Variants 1, 2, 4 and 5 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787

UniProtKB/Swiss-Prot

Q8BGI8
NM_001413653.1 → NP_001400582.1 regulator of G-protein signaling 6 isoform 3

Status: REVIEWED

Source sequence(s)

AC124390, AC154684, AC161055, CT033787

UniProtKB/TrEMBL

B1B1E4
NM_015812.5 → NP_056627.1 regulator of G-protein signaling 6 isoform 2

See identical proteins and their annotated locations for NP_056627.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. Variants 1, 2, 4 and 5 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787

Consensus CDS

CCDS79132.1

UniProtKB/Swiss-Prot

Q8BGI8, Q9Z2H2

Related

ENSMUSP00000143801.2, ENSMUST00000200911.4

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain

RNA

NR_182187.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787
NR_182188.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124390, AC154684, AC161055, CT025545, CT033787
NR_182189.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC124390, AC154684, AC161055, CT025545

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

82663325..83208835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244133.3 → XP_011242435.1 regulator of G-protein signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011242435.1

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_006516070.5 → XP_006516133.1 regulator of G-protein signaling 6 isoform X5

UniProtKB/TrEMBL

Q3UTM5

Related

ENSMUSP00000125256.3, ENSMUST00000161801.8

Conserved Domains (3) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011244137.4 → XP_011242439.1 regulator of G-protein signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011242439.1

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036157524.1 → XP_036013417.1 regulator of G-protein signaling 6 isoform X4

Conserved Domains (4) summary

smart00224
Location:189 → 250

GGL; G protein gamma subunit-like motifs

cd08737
Location:259 → 383

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:1 → 50

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:47 → 148

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036157522.1 → XP_036013415.1 regulator of G-protein signaling 6 isoform X2

Conserved Domains (4) summary

smart00224
Location:189 → 250

GGL; G protein gamma subunit-like motifs

cd08737
Location:259 → 383

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:1 → 50

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:47 → 148

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011244135.4 → XP_011242437.1 regulator of G-protein signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011242437.1

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011244134.4 → XP_011242436.1 regulator of G-protein signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011242436.1

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036157523.1 → XP_036013416.1 regulator of G-protein signaling 6 isoform X3

Related

ENSMUSP00000143961.2, ENSMUST00000202210.4

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011244136.3 → XP_011242438.1 regulator of G-protein signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011242438.1

Conserved Domains (4) summary

smart00224
Location:258 → 319

GGL; G protein gamma subunit-like motifs

cd08737
Location:328 → 452

RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

cd04450
Location:31 → 119

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:116 → 217

RGS_DHEX; Regulator of G-protein signalling DHEX domain