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RAB36 RAB36, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 9609, updated on 25-Jan-2022

Summary

Official Symbol
RAB36provided by HGNC
Official Full Name
RAB36, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9775
See related
Ensembl:ENSG00000100228 MIM:605662; AllianceGenome:HGNC:9775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in protein transport. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in thyroid (RPKM 6.1), kidney (RPKM 2.1) and 17 other tissues See more
Orthologs
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Genomic context

See RAB36 in Genome Data Viewer
Location:
22q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (23145298..23169285)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23487511..23507850)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene radial spoke head 14 homolog Neighboring gene G protein subunit alpha z Neighboring gene RNA, 7SL, cytoplasmic 6, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7478 Neighboring gene RAB36-BCR intergenic enhancer-blocking element 22-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-36
Names
small GTP-binding protein Rab36
NP_001336806.1
NP_001336807.1
NP_004905.3
XP_006724444.1
XP_011528846.1
XP_011528847.1
XP_011528848.1
XP_011528849.1
XP_011528852.1
XP_011528854.1
XP_016884593.1
XP_016884594.1
XP_016884595.1
XP_016884596.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349877.1NP_001336806.1  ras-related protein Rab-36 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB023061, AC000102, AF133588, BC017436, BC104991, BM681181, HY044604
    Conserved Domains (1) summary
    cd04108
    Location:148313
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
  2. NM_001349878.1NP_001336807.1  ras-related protein Rab-36 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region uses an alternate splice site in the 3' coding region, which results in a frameshift and a shorter 3' UTR, compared to variant 1. The encoded isoform (2) is shorter, lacks an internal segment and contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB023061, AC000102, AF133588, BC017436, BM681181, HY044604
    Conserved Domains (1) summary
    cl21455
    Location:124266
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_004914.5NP_004905.3  ras-related protein Rab-36 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC000029, AC000102
    Consensus CDS
    CCDS13805.1
    Related
    ENSP00000263116.3, ENST00000263116.8
    Conserved Domains (1) summary
    cd04108
    Location:58223
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

RNA

  1. NR_146295.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023061, AC000102, AF133588, BC017436, BM681181

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    23145298..23169285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530550.2XP_011528852.1  ras-related protein Rab-36 isoform X10

    Conserved Domains (1) summary
    cl21455
    Location:148229
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011530546.2XP_011528848.1  ras-related protein Rab-36 isoform X5

    Conserved Domains (1) summary
    cl21455
    Location:148290
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011530544.3XP_011528846.1  ras-related protein Rab-36 isoform X2

    Conserved Domains (2) summary
    PLN03118
    Location:149349
    PLN03118; Rab family protein; Provisional
    cl21455
    Location:148305
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_017029104.1XP_016884593.1  ras-related protein Rab-36 isoform X3

  5. XM_011530545.2XP_011528847.1  ras-related protein Rab-36 isoform X4

    Conserved Domains (2) summary
    smart00175
    Location:149308
    RAB; Rab subfamily of small GTPases
    cd04108
    Location:148313
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
  6. XM_006724381.4XP_006724444.1  ras-related protein Rab-36 isoform X1

    Conserved Domains (1) summary
    cl21455
    Location:148290
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_011530547.2XP_011528849.1  ras-related protein Rab-36 isoform X6

    Conserved Domains (1) summary
    cl21455
    Location:97239
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_017029105.1XP_016884594.1  ras-related protein Rab-36 isoform X7

  9. XM_017029107.1XP_016884596.1  ras-related protein Rab-36 isoform X9

  10. XM_017029106.1XP_016884595.1  ras-related protein Rab-36 isoform X8

  11. XM_011530552.2XP_011528854.1  ras-related protein Rab-36 isoform X11

    Conserved Domains (1) summary
    cl21455
    Location:40108
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_001755386.1 RNA Sequence

  2. XR_001755385.1 RNA Sequence

  3. XR_001755387.1 RNA Sequence

  4. XR_001755381.2 RNA Sequence

  5. XR_001755380.2 RNA Sequence

  6. XR_001755384.1 RNA Sequence

  7. XR_001755383.1 RNA Sequence

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