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RNF14 ring finger protein 14 [ Homo sapiens (human) ]

Gene ID: 9604, updated on 2-Oct-2018

Summary

Official Symbol
RNF14provided by HGNC
Official Full Name
ring finger protein 14provided by HGNC
Primary source
HGNC:HGNC:10058
See related
Ensembl:ENSG00000013561 MIM:605675; Vega:OTTHUMG00000129660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA54; HFB30; TRIAD2; HRIHFB2038
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See RNF14 in Genome Data Viewer
Location:
5q31.3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (141966807..141990291)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141346402..141369856)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-like protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF14
Names
androgen receptor associated protein 54
NP_001188294.1
NP_004281.1
NP_899645.1
NP_899646.1
NP_899647.1
NP_899648.1
XP_005268596.1
XP_005268597.1
XP_005268598.1
XP_005268599.1
XP_005268600.1
XP_011536016.1
XP_016865560.1
XP_016865561.1
XP_016865562.1
XP_016865563.1
XP_016865564.1
XP_024302033.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201365.1NP_001188294.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_001188294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, BC126185, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378027.1, ENST00000394519.5
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  2. NM_004290.4NP_004281.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_004281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378028.2, OTTHUMP00000160065, ENST00000394520.6, OTTHUMT00000251860
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  3. NM_183398.2NP_899645.1  E3 ubiquitin-protein ligase RNF14 isoform 2

    See identical proteins and their annotated locations for NP_899645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC005740, AF060544, BE042895, DB456366, DC402536
    Consensus CDS
    CCDS4271.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000378022.2, OTTHUMP00000160066, ENST00000394514.6, OTTHUMT00000251861
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  4. NM_183399.2NP_899646.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC396586
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000348462.1, ENST00000356143.5
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  5. NM_183400.2NP_899647.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC402536
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Related
    ENSP00000324956.3, ENST00000347642.7
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  6. NM_183401.2NP_899648.1  E3 ubiquitin-protein ligase RNF14 isoform 1

    See identical proteins and their annotated locations for NP_899648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC005740, AF060544, BE042895, DC358984
    Consensus CDS
    CCDS4270.1
    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    141966807..141990291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446265.1XP_024302033.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  2. XM_005268540.4XP_005268597.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    See identical proteins and their annotated locations for XP_005268597.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  3. XM_017010075.2XP_016865564.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  4. XM_005268541.4XP_005268598.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    See identical proteins and their annotated locations for XP_005268598.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  5. XM_005268542.3XP_005268599.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    See identical proteins and their annotated locations for XP_005268599.1

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  6. XM_005268543.5XP_005268600.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    See identical proteins and their annotated locations for XP_005268600.1

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  7. XM_011537714.3XP_011536016.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    See identical proteins and their annotated locations for XP_011536016.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (4) summary
    smart00647
    Location:289350
    IBR; In Between Ring fingers
    pfam01485
    Location:377433
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
    cd16628
    Location:218271
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
  8. XM_017010073.2XP_016865562.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
  9. XM_005268539.3XP_005268596.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    See identical proteins and their annotated locations for XP_005268596.1

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  10. XM_017010072.2XP_016865561.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  11. XM_017010071.2XP_016865560.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/Swiss-Prot
    Q9UBS8
    Conserved Domains (3) summary
    smart00647
    Location:163224
    IBR; In Between Ring fingers
    pfam01485
    Location:251307
    IBR; IBR domain, a half RING-finger domain
    pfam14634
    Location:94129
    zf-RING_5; zinc-RING finger domain
  12. XM_017010074.2XP_016865563.1  E3 ubiquitin-protein ligase RNF14 isoform X3

    UniProtKB/TrEMBL
    B7Z229
    Conserved Domains (3) summary
    smart00647
    Location:113174
    IBR; In Between Ring fingers
    pfam01485
    Location:201257
    IBR; IBR domain, a half RING-finger domain
    cl02687
    Location:779
    RWD; RWD domain
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