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GDF15 growth differentiation factor 15 [ Homo sapiens (human) ]

Gene ID: 9518, updated on 6-Dec-2016
Official Symbol
GDF15provided by HGNC
Official Full Name
growth differentiation factor 15provided by HGNC
Primary source
HGNC:HGNC:30142
See related
Ensembl:ENSG00000130513 MIM:605312; Vega:OTTHUMG00000183360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
Orthologs
Location:
19p13.11
Exon count:
2
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (18386158..18389176)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18496968..18499986)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 513, pseudogene Neighboring gene pyroglutamyl-peptidase I Neighboring gene microRNA 3189 Neighboring gene leucine rich repeat containing 25 Neighboring gene single stranded DNA binding protein 4 Neighboring gene inositol-3-phosphate synthase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
growth/differentiation factor 15
Names
NRG-1
NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
NSAID-activated gene 1 protein
NSAID-regulated gene 1 protein
PTGF-beta
macrophage inhibitory cytokine 1
placental TGF-beta
placental bone morphogenetic protein
prostate differentiation factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004864.3NP_004855.2  growth/differentiation factor 15 preproprotein

    See identical proteins and their annotated locations for NP_004855.2

    Status: REVIEWED

    Source sequence(s)
    BC008962, BQ901034, CA441527
    Consensus CDS
    CCDS12376.1
    UniProtKB/Swiss-Prot
    Q99988
    Related
    ENSP00000252809, OTTHUMP00000271537, ENST00000252809, OTTHUMT00000466340
    Conserved Domains (1) summary
    smart00204
    Location:211308
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    18386158..18389176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    18497209..18500231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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