Conserved Protein Domain Family
TGFB

?
smart00204: TGFB 
Click on image for an interactive view with Cn3D
Transforming growth factor-beta (TGF-beta) family
Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.
Statistics
?
PSSM-Id: 214556
View PSSM: smart00204
Aligned: 38 rows
Threshold Bit Score: 100.813
Threshold Setting Gi: 124273
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00204 is a member of the superfamily cl02510.
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BHK_A        19 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLE--P--T-NHAVIQT-LMNSMDP--Es-TP--PTCCV- 86
gi 311275862 319 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSG--SslS-FHSTVIN-HYRMRGH--Sp-FAnlKSCCV- 390
gi 73984168  361 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGsaS--S-FHTAVVN-QYRMRGL--NpgTV--NSCCI- 431
gi 55638399  247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGiaA--S-FHTAVLN-LLKANTAagTt-GG--GSCCV- 318
gi 30851670  340 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYG--S--P-VHTMVQNiIYEKLDP--S--VP--RPSCV- 407
gi 17552832  250 CCLYDLEIEFEKIGW-DWIVAPPRYNAYMCRGDCHYNAHHFNL--Ae-T-GHSKIMR-AAHKVS---Np-EI--GYCCH- 316
gi 1872554   211 CRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRAANM--------HAQIKT-SLHRLKP--Dt-EP--APCCV- 275
gi 296485611 477 CALRELSVDLRA---ERSVLIPETYQANNCQGACGWPQSDRNP--R--YgNHVVLLL-KMQARGA--Tl-AR--PPCCV- 542
gi 124273    256 CHRAALNISFQELGWDRWIVHPPSFIFYYCHGGCGLSPPQDLP--L--P-VPGVPPT-PVQPLSL--Vp-GA--QPCCAa 324
1NYS_B        11 CCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSG--SslS-FHSTVIN-HYRMRGH--Sp-FAnlKSCCV- 82
                         90       100       110
                 ....*....|....*....|....*....|....*.
2BHK_A        87 -PTRLSPISILFIDSANNVVYKQ-YEDMVVESCGCR 120
gi 311275862 391 -PTKLRPMSMLYYDDGQNIIKKD-IQNMIVEECGCS 424
gi 73984168  432 -PTKLSTMSMLYFDDEYNIVKRD-VPNMIVEECGCa 465
gi 55638399  319 -PTARRPLSLLYYDRDSNIVKTD-IPDMVVEACGCS 352
gi 30851670  408 -PGKYSPLSVLTIEPDGSIAYKE-YEDMIATRCTCR 441
gi 17552832  317 -PTEYDYIKLIYVNRDGRVSIAN-VNGMIAKKCGCS 350
gi 1872554   276 -PASYNPMVLIQKTDTG-VSLQT-YDDLLAKDCHCI 308
gi 296485611 543 -PTAYTGKLLISLSEE-RISAHH-VPNMVATECGCR 575
gi 124273    325 lPGTMRPLHVRTTSDGGYSFKYEmVPNLLTQHCACI 360
1NYS_B        83 -PTKLRPMSMLYYDDGQNIIKKD-IQNMIVEECGCS 116
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap