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GAL3ST1 galactose-3-O-sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 9514, updated on 4-Jun-2020

Summary

Official Symbol
GAL3ST1provided by HGNC
Official Full Name
galactose-3-O-sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:24240
See related
Ensembl:ENSG00000128242 MIM:602300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CST
Summary
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in kidney (RPKM 2.0), duodenum (RPKM 1.8) and 9 other tissues See more
Orthologs

Genomic context

See GAL3ST1 in Genome Data Viewer
Location:
22q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30554635..30574665, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30950622..30970572, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SEC14 like lipid binding 4 Neighboring gene SEC14 like lipid binding 6 Neighboring gene signal regulatory protein alpha pseudogene 1 Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene Sharpr-MPRA regulatory region 4664 Neighboring gene transcobalamin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
galactose 3-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactosylceramide sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
galactosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
galactosylceramide sulfotransferase
Names
3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase
cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase
NP_001305032.1
NP_001305033.1
NP_001305034.1
NP_001305035.1
NP_001305036.1
NP_001305037.1
NP_001305038.1
NP_001305039.1
NP_001305040.1
NP_001305041.1
NP_001305042.1
NP_001305043.1
NP_001305044.1
NP_001305045.1
NP_004852.1
XP_011528820.1
XP_011528824.1
XP_011528826.1
XP_011528830.1
XP_016884585.1
XP_016884586.1
XP_016884587.1
XP_024308072.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318103.2NP_001305032.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AC005006, AW137588, BM923857, D88667, DA372454
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Related
    ENSP00000384122.1, ENST00000402369.5
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  2. NM_001318104.2NP_001305033.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AC005006, AW137588, BM923857, D88667, DA271385
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Related
    ENSP00000385207.1, ENST00000406361.6
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  3. NM_001318105.2NP_001305034.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AK313097, AW137588, D88667, DA384904
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7, B2R7S4
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  4. NM_001318106.2NP_001305035.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1). Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, D88667, DA384904
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  5. NM_001318107.2NP_001305036.1  galactosylceramide sulfotransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 13 and 14 encode the same isoform (2).
    Source sequence(s)
    AC005006, AW137588, D88667, DA382951
    UniProtKB/Swiss-Prot
    Q99999
    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  6. NM_001318108.2NP_001305037.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, D88667, DA376354, DA384904
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  7. NM_001318109.1NP_001305038.1  galactosylceramide sulfotransferase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (3) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AW137588, BP220526, D88667, DA384904
    UniProtKB/Swiss-Prot
    Q99999
    Conserved Domains (1) summary
    pfam06990
    Location:26433
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  8. NM_001318110.2NP_001305039.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, D88667, DA379889, DA381062
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  9. NM_001318111.2NP_001305040.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, BU584341, D88667, DA371478, DA381062
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Related
    ENSP00000385735.1, ENST00000402321.5
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  10. NM_001318112.2NP_001305041.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, BC019077, BP276494, D88667
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Related
    ENSP00000385825.1, ENST00000406955.5
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  11. NM_001318113.2NP_001305042.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, BC014649, BP276494, D88667
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  12. NM_001318114.2NP_001305043.1  galactosylceramide sulfotransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. Both variants 13 and 14 encode the same isoform (2).
    Source sequence(s)
    AW137588, BP276494, D88667, DA381099
    UniProtKB/Swiss-Prot
    Q99999
    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  13. NM_001318115.2NP_001305044.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AC005006, AW137588, BG419785, BP276494, D88667
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  14. NM_001318116.2NP_001305045.1  galactosylceramide sulfotransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, BP276494, D88667, DA370553
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  15. NM_004861.3NP_004852.1  galactosylceramide sulfotransferase isoform 1

    See identical proteins and their annotated locations for NP_004852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-12 encode the same isoform (1).
    Source sequence(s)
    AW137588, D88667, DA381062
    Consensus CDS
    CCDS13879.1
    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Related
    ENSP00000384388.1, ENST00000401975.5
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30554635..30574665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530524.1XP_011528826.1  galactosylceramide sulfotransferase isoform X2

    See identical proteins and their annotated locations for XP_011528826.1

    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  2. XM_011530518.2XP_011528820.1  galactosylceramide sulfotransferase isoform X1

    Conserved Domains (1) summary
    pfam06990
    Location:27435
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  3. XM_011530522.2XP_011528824.1  galactosylceramide sulfotransferase isoform X2

    See identical proteins and their annotated locations for XP_011528824.1

    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  4. XM_017029097.1XP_016884586.1  galactosylceramide sulfotransferase isoform X2

    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  5. XM_024452304.1XP_024308072.1  galactosylceramide sulfotransferase isoform X3

    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  6. XM_017029098.1XP_016884587.1  galactosylceramide sulfotransferase isoform X3

    UniProtKB/Swiss-Prot
    Q99999
    UniProtKB/TrEMBL
    A0A024R1D7
    Conserved Domains (1) summary
    pfam06990
    Location:1408
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  7. XM_017029096.1XP_016884585.1  galactosylceramide sulfotransferase isoform X2

    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
  8. XM_011530528.1XP_011528830.1  galactosylceramide sulfotransferase isoform X2

    See identical proteins and their annotated locations for XP_011528830.1

    Conserved Domains (1) summary
    pfam06990
    Location:1409
    Gal-3-0_sulfotr; Galactose-3-O-sulfotransferase
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