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Gal3st1 galactose-3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 53897, updated on 12-May-2024

Summary

Official Symbol
Gal3st1provided by MGI
Official Full Name
galactose-3-O-sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1858277
See related
Ensembl:ENSMUSG00000049721 AllianceGenome:MGI:1858277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cst; Gcst
Summary
Enables galactosylceramide sulfotransferase activity. Involved in galactosylceramide metabolic process. Acts upstream of or within galactosylceramide biosynthetic process; myelination; and spermatogenesis. Predicted to be integral component of membrane. Is expressed in brain; future spinal cord; heart ventricle; and spinal cord cervical region. Orthologous to human GAL3ST1 (galactose-3-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 105.3), duodenum adult (RPKM 57.3) and 7 other tissues See more
Orthologs
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Genomic context

See Gal3st1 in Genome Data Viewer
Location:
11 A1; 11 2.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3933636..3949328)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3983636..3999328)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables galactosylceramide sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables galactosylceramide sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables galactosylceramide sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables galactosylceramide sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
galactosylceramide sulfotransferase
Names
3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase
3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase
Galcer sulfotransferase
cerebroside sulfotransferase
NP_001171162.1
NP_001171174.1
NP_001369219.1
NP_001369220.1
NP_058618.2
XP_006514819.2
XP_006514820.1
XP_036012743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177691.1NP_001171162.1  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_001171162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as form E) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK002510, AK007645, AL807395, BB804195
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000105608.2, ENSMUST00000109981.2
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family
  2. NM_001177703.1NP_001171174.1  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_001171174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK007645, AL807395, BB804195, CX239940
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000077815.2, ENSMUST00000078757.8
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family
  3. NM_001382290.1NP_001369219.1  galactosylceramide sulfotransferase

    Status: VALIDATED

    Source sequence(s)
    AL807395
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family
  4. NM_001382291.1NP_001369220.1  galactosylceramide sulfotransferase

    Status: VALIDATED

    Source sequence(s)
    AL807395
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family
  5. NM_016922.3NP_058618.2  galactosylceramide sulfotransferase

    See identical proteins and their annotated locations for NP_058618.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as form A) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it would be inhibited by an overlapping uORF with a strong Kozak sequence.
    Source sequence(s)
    AK007645, AL807395, BB804195, CX239940
    Consensus CDS
    CCDS24373.1
    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Related
    ENSMUSP00000058348.8, ENSMUST00000063004.14
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3933636..3949328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156850.1XP_036012743.1  galactosylceramide sulfotransferase isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:28437
    Sulfotransfer_2; Sulfotransferase family
  2. XM_006514757.5XP_006514820.1  galactosylceramide sulfotransferase isoform X1

    See identical proteins and their annotated locations for XP_006514820.1

    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family
  3. XM_006514756.5XP_006514819.2  galactosylceramide sulfotransferase isoform X1

    See identical proteins and their annotated locations for XP_006514819.2

    UniProtKB/Swiss-Prot
    Q9D8V6, Q9JHE4
    Conserved Domains (1) summary
    cl22970
    Location:4408
    Sulfotransfer_2; Sulfotransferase family