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MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 9479, updated on 7-Dec-2018

Summary

Official Symbol
MAPK8IP1provided by HGNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:6882
See related
Ensembl:ENSG00000121653 MIM:604641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IB1; JIP1; JIP-1; PRKM8IP
Summary
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Expression
Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues See more
Orthologs

Genomic context

See MAPK8IP1 in Genome Data Viewer
Location:
11p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (45885496..45906465)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45907047..45928016)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member C1 Neighboring gene cryptochrome circadian regulator 2 Neighboring gene chromosome 11 open reading frame 94 Neighboring gene peroxisomal biogenesis factor 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from BioSystems

  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase binding IEA
Inferred from Electronic Annotation
more info
 
MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JUN phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of CD8-positive, alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendritic growth cone IEA
Inferred from Electronic Annotation
more info
 
dentate gyrus mossy fiber IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 1
Names
IB-1
JNK MAP kinase scaffold protein 1
JNK-interacting protein 1
PRKM8 interacting protein
islet-brain 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012153.1 RefSeqGene

    Range
    4846..25815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005456.4NP_005447.1  C-Jun-amino-terminal kinase-interacting protein 1

    See identical proteins and their annotated locations for NP_005447.1

    Status: REVIEWED

    Source sequence(s)
    AF007134, AF074091, BC068470
    Consensus CDS
    CCDS7916.1
    UniProtKB/Swiss-Prot
    Q9UQF2
    UniProtKB/TrEMBL
    Q6NUQ9
    Related
    ENSP00000241014.2, ENST00000241014.6
    Conserved Domains (2) summary
    cd11943
    Location:492546
    SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
    cd01212
    Location:563711
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    45885496..45906465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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