U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 19099, updated on 20-Jun-2024

Summary

Official Symbol
Mapk8ip1provided by MGI
Official Full Name
mitogen-activated protein kinase 8 interacting protein 1provided by MGI
Primary source
MGI:MGI:1309464
See related
Ensembl:ENSMUSG00000027223 AllianceGenome:MGI:1309464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IB1; Jip1; Skip; JIP-1; Prkm8ip; mjip-2a
Summary
Enables kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including cell body; dendrite; and dentate gyrus mossy fiber. Is expressed in intestine smooth muscle circular layer; nervous system; renal vasculature; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 70.7), cortex adult (RPKM 62.2) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mapk8ip1 in Genome Data Viewer
Location:
2 E1; 2 50.99 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92214021..92231608, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92383671..92401346, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1247 Neighboring gene STARR-positive B cell enhancer ABC_E4480 Neighboring gene peroxisomal biogenesis factor 16 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene microRNA 7000 Neighboring gene RIKEN cDNA D930015M05 gene Neighboring gene cryptochrome circadian regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E1248 Neighboring gene STARR-positive B cell enhancer ABC_E4481 Neighboring gene solute carrier family 35, member C1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic growth cone ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in dentate gyrus mossy fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 1
Names
IB-1
JNK MAP kinase scaffold protein 1
JNK-interacting protein 1
islet-brain-1
protein kinase, mitogen-activated 8 interacting protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202445.1NP_001189374.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001189374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK147033, BC072578
    Consensus CDS
    CCDS57180.1
    UniProtKB/TrEMBL
    Q6GQW8
    Related
    ENSMUSP00000106910.3, ENSMUST00000111279.9
    Conserved Domains (2) summary
    cd11943
    Location:479533
    SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
    cd01212
    Location:550698
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
  2. NM_001202446.1NP_001189375.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001189375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AK147033, BC072578
    UniProtKB/TrEMBL
    Q3UI81
    Conserved Domains (2) summary
    cd11943
    Location:454508
    SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
    cd01212
    Location:525673
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
  3. NM_011162.5NP_035292.2  C-Jun-amino-terminal kinase-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035292.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL731709, BC072578
    Consensus CDS
    CCDS16446.1
    UniProtKB/Swiss-Prot
    O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8, Q9WVI9
    UniProtKB/TrEMBL
    Q6GQW8
    Related
    ENSMUSP00000050773.3, ENSMUST00000050312.3
    Conserved Domains (2) summary
    cd11943
    Location:488542
    SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
    cd01212
    Location:559707
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    92214021..92231608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)