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IL27RA interleukin 27 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 9466, updated on 13-Mar-2020

Summary

Official Symbol
IL27RAprovided by HGNC
Official Full Name
interleukin 27 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:17290
See related
Ensembl:ENSG00000104998 MIM:605350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRL1; TCCR; WSX1; IL27R; IL-27RA; zcytor1
Summary
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 12.2), appendix (RPKM 9.7) and 22 other tissues See more
Orthologs

Genomic context

See IL27RA in Genome Data Viewer
Location:
19p13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14031762..14053218)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14142552..14163731)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.2299 Neighboring gene relaxin 3 Neighboring gene paralemmin 3 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IL27RA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-27 receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-27-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-35-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of T cell extravasation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T-helper 17 type immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-17 secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-27 receptor subunit alpha
Names
IL-27 receptor subunit alpha
IL-27R subunit alpha
IL-27R-alpha
T-cell cytokine receptor type 1
class I cytokine receptor
cytokine receptor WSX-1
cytokine receptor-like 1
interleukin 27 receptor, alpha
type I T-cell cytokine receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004843.4NP_004834.1  interleukin-27 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_004834.1

    Status: REVIEWED

    Source sequence(s)
    AC022098, AF053004, AF106912
    Consensus CDS
    CCDS12303.1
    UniProtKB/Swiss-Prot
    Q6UWB1
    Related
    ENSP00000263379.1, ENST00000263379.4
    Conserved Domains (2) summary
    cd00063
    Location:128228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:321394
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14031762..14053218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p13 PATCHES

    Range
    243603..265059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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