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Il27ra interleukin 27 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 50931, updated on 8-Feb-2024

Summary

Official Symbol
Il27raprovided by MGI
Official Full Name
interleukin 27 receptor, alphaprovided by MGI
Primary source
MGI:MGI:1355318
See related
Ensembl:ENSMUSG00000005465 AllianceGenome:MGI:1355318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1
Summary
Enables interleukin-27 receptor activity. Involved in negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 26.4), thymus adult (RPKM 23.9) and 8 other tissues See more
Orthologs
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Genomic context

See Il27ra in Genome Data Viewer
Location:
8 C2; 8 40.26 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84756915..84769250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84030286..84042600, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 1199 Neighboring gene MISP family member 3 Neighboring gene paralemmin 3 Neighboring gene predicted gene, 53445 Neighboring gene relaxin 3 Neighboring gene STARR-seq mESC enhancer starr_22106 Neighboring gene predicted gene 10643 Neighboring gene regulatory factor X, 1 (influences HLA class II expression)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-27 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-27 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of T-helper 17 type immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cellular extravasation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interleukin-17 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
interleukin-27 receptor subunit alpha
Names
IL-27 receptor subunit alpha
IL-27R subunit alpha
IL-27R-alpha
IL-27RA
T cell cytokine receptor
T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
cytokine receptor family, class 1 (WSXWS), member 1
type I T-cell cytokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425585.1NP_001412514.1  interleukin-27 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156028
    UniProtKB/TrEMBL
    Q3UZN3
  2. NM_016671.4NP_057880.2  interleukin-27 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_057880.2

    Status: VALIDATED

    Source sequence(s)
    AC156028
    Consensus CDS
    CCDS22465.1
    UniProtKB/Swiss-Prot
    E9QNY4, O70394
    UniProtKB/TrEMBL
    Q3UZN3
    Related
    ENSMUSP00000005601.8, ENSMUST00000005601.9
    Conserved Domains (1) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84756915..84769250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154161.1XP_036010054.1  interleukin-27 receptor subunit alpha isoform X3

    Conserved Domains (1) summary
    cl21522
    Location:93172
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011248437.3XP_011246739.1  interleukin-27 receptor subunit alpha isoform X2

    Conserved Domains (2) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:315394
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_036154162.1XP_036010055.1  interleukin-27 receptor subunit alpha isoform X4

    Conserved Domains (1) summary
    cd00063
    Location:123222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...