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NCR1 natural cytotoxicity triggering receptor 1 [ Homo sapiens (human) ]

Gene ID: 9437, updated on 25-Nov-2025
Official Symbol
NCR1provided by HGNC
Official Full Name
natural cytotoxicity triggering receptor 1provided by HGNC
Primary source
HGNC:HGNC:6731
See related
Ensembl:ENSG00000189430 MIM:604530; AllianceGenome:HGNC:6731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY94; CD335; NKP46; NK-p46
Summary
Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See NCR1 in Genome Data Viewer
Location:
19q13.42
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54898198..54938208)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57992503..58033237)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55417506..55424441)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3560 silencer Neighboring gene RNA, U6 small nuclear 222, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15416 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55404005-55404755 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55404756-55405506 Neighboring gene Fc alpha receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55431695-55432196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55432197-55432696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55450505-55451214 Neighboring gene NLR family pyrin domain containing 7 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:55461990-55462680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55463371-55464060 Neighboring gene ribosomal protein L36a pseudogene 50 Neighboring gene NLR family pyrin domain containing 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55523225-55523784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55526346-55526910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55527390-55527890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55527891-55528391 Neighboring gene GP6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55538985-55539689 Neighboring gene glycoprotein VI platelet

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ99094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables immune receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SWI/SNF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
natural cytotoxicity triggering receptor 1
Names
NK cell-activating receptor
lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
natural killer cell p46-related protein
NP_001138929.2

Length

  • 303
NP_001138930.2

Length

  • 287
NP_001229285.1

Length

  • 209
NP_001229286.1

Length

  • 192
NP_004820.2

Length

  • 304

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145457.3NP_001138929.2  natural cytotoxicity triggering receptor 1 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC011476, AC245128, AJ001383, BC064806
    Consensus CDS
    CCDS46181.1
    UniProtKB/TrEMBL
    A0A0A0MTU0, A0AAZ3WSD1
    Related
    ENSP00000471986.1, ENST00000594765.5
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  2. NM_001145458.3NP_001138930.2  natural cytotoxicity triggering receptor 1 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c) compared to isoform a.
    Source sequence(s)
    AC011476, AC245128, AJ001383, AJ006121
    Consensus CDS
    CCDS46182.1
    UniProtKB/TrEMBL
    A0A0A0MR94, A0AAZ3WPS1
    Related
    ENSP00000339515.4, ENST00000338835.9
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  3. NM_001242356.3NP_001229285.1  natural cytotoxicity triggering receptor 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001229285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region compared variant 1. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AC011476, AC245128, AJ001383, AJ006123
    Consensus CDS
    CCDS56103.1
    UniProtKB/Swiss-Prot
    O76036
    Related
    ENSP00000344358.4, ENST00000350790.9
    Conserved Domains (1) summary
    cd05711
    Location:28115
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  4. NM_001242357.3NP_001229286.1  natural cytotoxicity triggering receptor 1 isoform e precursor

    See identical proteins and their annotated locations for NP_001229286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform e) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AC011476, AC245128, AJ001383, AJ006123
    UniProtKB/Swiss-Prot
    O76036
    Conserved Domains (1) summary
    cd05711
    Location:28115
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  5. NM_004829.7NP_004820.2  natural cytotoxicity triggering receptor 1 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC011476, AC245128, AJ001383
    Consensus CDS
    CCDS12911.1
    UniProtKB/Swiss-Prot
    B0V3L2, B0V3L3, B0V3L4, B0V3L5, B8JL03, O76016, O76017, O76018, O76036
    UniProtKB/TrEMBL
    A0A0A0MQZ0, A0AAZ3WNK6
    Related
    ENSP00000291890.3, ENST00000291890.9
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54898198..54938208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439727.1XP_047295683.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_011527530.4XP_011525832.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  3. XM_011527529.4XP_011525831.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107304.1 Reference GRCh38.p14 PATCHES

    Range
    235221..239170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107312.1 Reference GRCh38.p14 PATCHES

    Range
    1889..5838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    801588..841606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329706.1XP_054185681.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054329705.1XP_054185680.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054329704.1XP_054185679.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    543372..584149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330207.1XP_054186182.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054330206.1XP_054186181.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054330205.1XP_054186180.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    878176..918933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330503.1XP_054186478.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054330502.1XP_054186477.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054330501.1XP_054186476.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    905713..946470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330753.1XP_054186728.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054330752.1XP_054186727.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054330751.1XP_054186726.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    880262..921019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330984.1XP_054186959.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054330983.1XP_054186958.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054330982.1XP_054186957.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    816555..856573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331267.1XP_054187242.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054331266.1XP_054187241.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054331265.1XP_054187240.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    802558..842560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331537.1XP_054187512.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054331536.1XP_054187511.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054331535.1XP_054187510.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

    Range
    610351..651108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333581.1XP_054189556.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054333580.1XP_054189555.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054333579.1XP_054189554.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    880672..920690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333683.1XP_054189658.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054333682.1XP_054189657.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054333681.1XP_054189656.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44

Reference GRCh38.p14 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p14 ALT_REF_LOCI_23

    Range
    185095..189044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p14 ALT_REF_LOCI_26

    Range
    192168..196117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p14 ALT_REF_LOCI_27

    Range
    276387..280336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p14 ALT_REF_LOCI_28

    Range
    182098..186047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p14 ALT_REF_LOCI_29

    Range
    183515..187464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p14 ALT_REF_LOCI_30

    Range
    180366..184315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57992503..58033237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322692.1XP_054178667.1  natural cytotoxicity triggering receptor 1 isoform X3

  2. XM_054322691.1XP_054178666.1  natural cytotoxicity triggering receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JM44
  3. XM_054322690.1XP_054178665.1  natural cytotoxicity triggering receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JM44