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NCR1 natural cytotoxicity triggering receptor 1 [ Homo sapiens (human) ]

Gene ID: 9437, updated on 23-Dec-2018

Summary

Official Symbol
NCR1provided by HGNC
Official Full Name
natural cytotoxicity triggering receptor 1provided by HGNC
Primary source
HGNC:HGNC:6731
See related
Ensembl:ENSG00000189430 MIM:604530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY94; CD335; NKP46; NK-p46
Expression
Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues See more
Orthologs

Genomic context

See NCR1 in Genome Data Viewer
Location:
19q13.42
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (54906063..54938211)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55417504..55424454)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 222, pseudogene Neighboring gene Fc fragment of IgA receptor Neighboring gene NLR family pyrin domain containing 7 Neighboring gene ribosomal protein L36a pseudogene 50 Neighboring gene NLR family pyrin domain containing 2 Neighboring gene uncharacterized LOC107985325 Neighboring gene glycoprotein VI platelet

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
natural killer cell activation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of natural killer cell mediated cytotoxicity TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
SWI/SNF complex ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
natural cytotoxicity triggering receptor 1
Names
NK cell-activating receptor
lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
natural killer cell p46-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145457.2NP_001138929.2  natural cytotoxicity triggering receptor 1 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC245128, AJ001383, BC064806
    Consensus CDS
    CCDS46181.1
    UniProtKB/Swiss-Prot
    O76036
    UniProtKB/TrEMBL
    A0A0A0MTU0
    Related
    ENSP00000471986.1, ENST00000594765.5
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  2. NM_001145458.2NP_001138930.2  natural cytotoxicity triggering receptor 1 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c) compared to isoform a.
    Source sequence(s)
    AC245128, AJ001383, AJ006121
    Consensus CDS
    CCDS46182.1
    UniProtKB/Swiss-Prot
    O76036
    UniProtKB/TrEMBL
    A0A0A0MR94
    Related
    ENSP00000339515.4, ENST00000338835.9
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  3. NM_001242356.2NP_001229285.1  natural cytotoxicity triggering receptor 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001229285.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region compared variant 1. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AJ001383, AJ006123
    Consensus CDS
    CCDS56103.1
    UniProtKB/Swiss-Prot
    O76036
    Related
    ENSP00000344358.4, ENST00000350790.9
    Conserved Domains (1) summary
    cd05711
    Location:28115
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  4. NM_001242357.2NP_001229286.1  natural cytotoxicity triggering receptor 1 isoform e precursor

    See identical proteins and their annotated locations for NP_001229286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform e) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AJ001383, AJ006123
    UniProtKB/Swiss-Prot
    O76036
    Conserved Domains (1) summary
    cd05711
    Location:28115
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  5. NM_004829.6NP_004820.2  natural cytotoxicity triggering receptor 1 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC245128, AJ001383
    Consensus CDS
    CCDS12911.1
    UniProtKB/Swiss-Prot
    O76036
    UniProtKB/TrEMBL
    A0A0A0MQZ0
    Related
    ENSP00000291890.3, ENST00000291890.8
    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    54906063..54938211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527528.3XP_011525830.1  natural cytotoxicity triggering receptor 1 isoform X1

    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  2. XM_011527529.3XP_011525831.1  natural cytotoxicity triggering receptor 1 isoform X2

    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  3. XM_011527530.3XP_011525832.1  natural cytotoxicity triggering receptor 1 isoform X3

    Conserved Domains (2) summary
    cd05711
    Location:123210
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:27118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

RNA

  1. XR_001753801.2 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107304.1 Reference GRCh38.p12 PATCHES

    Range
    235223..239170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107312.1 Reference GRCh38.p12 PATCHES

    Range
    1889..5836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    809538..816469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    551333..558261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    886126..893057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    913663..920594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    888212..895143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    824505..831436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    810507..817421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p12 ALT_REF_LOCI_8

    Range
    618301..625232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

    Range
    888622..895553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p12 ALT_REF_LOCI_23

    Range
    185097..189044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p12 ALT_REF_LOCI_26

    Range
    192170..196117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p12 ALT_REF_LOCI_27

    Range
    276389..280336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p12 ALT_REF_LOCI_28

    Range
    182100..186047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p12 ALT_REF_LOCI_29

    Range
    183517..187464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p12 ALT_REF_LOCI_30

    Range
    180368..184315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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