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TNFRSF8 TNF receptor superfamily member 8 [ Homo sapiens (human) ]

Gene ID: 943, updated on 12-Aug-2018

Summary

Official Symbol
TNFRSF8provided by HGNC
Official Full Name
TNF receptor superfamily member 8provided by HGNC
Primary source
HGNC:HGNC:11923
See related
Ensembl:ENSG00000120949 MIM:153243; Vega:OTTHUMG00000001827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD30; Ki-1; D1S166E
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 1.3), fat (RPKM 1.0) and 17 other tissues See more
Orthologs

Genomic context

See TNFRSF8 in Genome Data Viewer
Location:
1p36.22
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (12063317..12144213)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12123434..12204264)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene migration and invasion inhibitory protein Neighboring gene microRNA 6729 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene Neighboring gene RNA, U6 small nuclear 777, pseudogene Neighboring gene ribosomal protein L23a pseudogene 89 Neighboring gene TNF receptor superfamily member 1B Neighboring gene microRNA 7846 Neighboring gene microRNA 4632

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of TNFRSF8 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed
Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) in Vif-expression T cells PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 8 (TNFRSF8, CD30) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
    TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...
  • TNFs bind their physiological receptors, organism-specific biosystem (from REACTOME)
    TNFs bind their physiological receptors, organism-specific biosystemMembers of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquir...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 8
Names
CD30L receptor
Ki-1 antigen
cytokine receptor CD30
lymphocyte activation antigen CD30

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029573.2 RefSeqGene

    Range
    5001..85831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243.4NP_001234.3  tumor necrosis factor receptor superfamily member 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001234.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL357835, BC136400, BC141804, M83554
    Consensus CDS
    CCDS144.1
    UniProtKB/Swiss-Prot
    P28908
    UniProtKB/TrEMBL
    A5D8T4
    Related
    ENSP00000263932.2, OTTHUMP00000001783, ENST00000263932.6, OTTHUMT00000005130
    Conserved Domains (1) summary
    cd13409
    Location:17131
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  2. NM_001281430.2NP_001268359.2  tumor necrosis factor receptor superfamily member 8 isoform 3

    See identical proteins and their annotated locations for NP_001268359.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AL357835, BC136400, BC141804, M83554
    Consensus CDS
    CCDS59989.1
    UniProtKB/Swiss-Prot
    P28908
    UniProtKB/TrEMBL
    A5D8T4
    Related
    ENSP00000390650.2, ENST00000417814.3
    Conserved Domains (2) summary
    cd13409
    Location:62195
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    cl22855
    Location:120
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    12063317..12144213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542441.3XP_011540743.1  tumor necrosis factor receptor superfamily member 8 isoform X1

    Conserved Domains (1) summary
    cd13409
    Location:17131
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
  2. XM_011542443.2XP_011540745.1  tumor necrosis factor receptor superfamily member 8 isoform X2

    Conserved Domains (2) summary
    cd13409
    Location:62195
    TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30
    cl22855
    Location:120
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152942.2: Suppressed sequence

    Description
    NM_152942.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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