Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf8provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 8provided by MGI
Primary source: MGI:MGI:99908
See related: Ensembl:ENSMUSG00000028602 AllianceGenome:MGI:99908
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ki; Cd30; Ki-1; D1S166E
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Is expressed in several structures, including adrenal gland; brain; female reproductive system; intestine; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 4.6), testis adult (RPKM 0.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 78.17 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (144993702..145041734, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (145267132..145315164, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
Title: CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
Title: Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation.
CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
Title: CD30L/CD30 signaling regulates the formation of the tumor immune microenvironment and inhibits intestinal tumor development of colitis-associated colon cancer in mice.
chronic CD30 signaling increases the risk of B-cell lymphomagenesis.
Title: Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
This study demonstrated the amelioration of MOG35-55 peptide-induced active EAE in CD30 KO mice. CD30 was expressed limitedly on CD4 T cells at the induction phase of experimental autoimmune encephalomyelitis.
Title: Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis.
Data indicate that CD30L/CD30 axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).
Title: CD30 ligand is a new therapeutic target for central nervous system autoimmunity.
role in the maintenance and activation of IL-17A-producing gammadelta T cells
Title: CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice.
These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vgamma1(-) Vgamma4(-) gammadelta T cells bearing Vgamma6 at an early stage of BCG infection.
Title: CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.
Interference of the CD30-CD30L pathway reduces atherosclerosis development.
Title: Interference of the CD30-CD30L pathway reduces atherosclerosis development.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

Tnfrsf8 (e-PCR), detects polymorphism
- UniSTS:144660

Homology

Homologs of the Tnfrsf8 gene: The Tnfrsf8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 308 organisms have orthologs with human gene Tnfrsf8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TRAIL production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 8

Names: CD30L receptor; lymphocyte activation antigen CD30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009401.3 → NP_033427.1 tumor necrosis factor receptor superfamily member 8 precursor

See identical proteins and their annotated locations for NP_033427.1

Status: VALIDATED

Source sequence(s)

AL627099

Consensus CDS

CCDS18915.1

UniProtKB/Swiss-Prot

A1L3C9, Q60846

UniProtKB/TrEMBL

A1L3C9

Related

ENSMUSP00000030339.7, ENSMUST00000030339.13

Conserved Domains (1) summary

cd13409
Location:3 → 127

TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

144993702..145041734 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163966.1 → XP_036019859.1 tumor necrosis factor receptor superfamily member 8 isoform X1

Conserved Domains (2) summary

PTZ00449
Location:117 → 274

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd13409
Location:6 → 112

TNFRSF8; Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), also known as CD30