Format

Send to:

Choose Destination

CD80 CD80 molecule [ Homo sapiens (human) ]

Gene ID: 941, updated on 24-Dec-2019

Summary

Official Symbol
CD80provided by HGNC
Official Full Name
CD80 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1700
See related
Ensembl:ENSG00000121594 MIM:112203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
Summary
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in appendix (RPKM 2.0), lymph node (RPKM 1.9) and 24 other tissues See more
Orthologs

Genomic context

See CD80 in Genome Data Viewer
Location:
3q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119524293..119559614, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119243140..119278481, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39A Neighboring gene protein O-glucosyltransferase 1 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene cysteine and glycine rich protein 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12076 Neighboring gene uncharacterized LOC107986118 Neighboring gene ADP-ribosylarginine hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
NHGRI GWA Catalog
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
NHGRI GWA Catalog
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
NHGRI GWA Catalog
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
env The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation PubMed
env Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells PubMed
env The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28 PubMed
Nef nef HIV-1 Nef induces upregulation of CD80, CD83, and CD86 protein expression in a concentration dependent fashion in monocyte derived dendritic cells PubMed
nef HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays PubMed
nef HIV-1 Nef downregulates the co-stimulatory molecule CD80 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells PubMed
nef HIV-1 Nef-induced B-cell differentiation response is suppressed by monoclonal antibodies to cell surface molecule B7, indicating an interaction between Nef and B7 PubMed
nef HIV-1 Nef binds to the cytosolic tails of CD80 and CD86 to mediate their internalization PubMed
nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
nef HIV-1 Nef relocates cell-surface MHC-I, CD80, and CD86 to intracellular compartments and the Nef-mediated internalization is dependent on mediators of actin polymerization PubMed
Pr55(Gag) gag Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
Vpr vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
capsid gag The immobilization of HIV-1 p24 antigen on the micelles upregulates the expression of cell surface markers CD80 and CD86 in human dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
coreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T-helper 1 cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of interleukin-2 biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface HDA PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein complex involved in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-lymphocyte activation antigen CD80
Names
B-lymphocyte activation antigen B7
CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
CTLA-4 counter-receptor B7.1
activation B7-1 antigen
costimulatory factor CD80
costimulatory molecule variant IgV-CD80

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005191.4NP_005182.1  T-lymphocyte activation antigen CD80 precursor

    See identical proteins and their annotated locations for NP_005182.1

    Status: REVIEWED

    Source sequence(s)
    AC073352, BC042665, BP225173
    Consensus CDS
    CCDS2989.1
    UniProtKB/Swiss-Prot
    P33681
    UniProtKB/TrEMBL
    A0N0P2
    Related
    ENSP00000264246.3, ENST00000264246.8
    Conserved Domains (2) summary
    cd16083
    Location:142232
    IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
    cd16086
    Location:35139
    IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    119524293..119559614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center