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Cd80 CD80 antigen [ Mus musculus (house mouse) ]

Gene ID: 12519, updated on 17-Oct-2021

Summary

Official Symbol
Cd80provided by MGI
Official Full Name
CD80 antigenprovided by MGI
Primary source
MGI:MGI:101775
See related
Ensembl:ENSMUSG00000075122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Cd80 in Genome Data Viewer
Location:
16 B4; 16 26.86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38277793..38316682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38457430..38495958)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (38459013..38487015)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36333 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene predicted gene, 41453 Neighboring gene creatine kinase pseudogene 3 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene Neighboring gene predicted gene, 53953 Neighboring gene protein O-glucosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
T-lymphocyte activation antigen CD80
Names
B7 protein
activation B7-1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359898.1NP_001346827.1  T-lymphocyte activation antigen CD80 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC209577
    Consensus CDS
    CCDS28168.1
    Conserved Domains (2) summary
    cd16083
    Location:145235
    IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
    cd16086
    Location:39142
    IgV_CD80; Immunoglobulin variable domain (IgV) in CD80
  2. NM_009855.2NP_033985.3  T-lymphocyte activation antigen CD80 precursor

    See identical proteins and their annotated locations for NP_033985.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154425, X60958
    Consensus CDS
    CCDS28168.1
    UniProtKB/Swiss-Prot
    Q00609
    UniProtKB/TrEMBL
    Q549R2
    Related
    ENSMUSP00000097404.3, ENSMUST00000099816.3
    Conserved Domains (2) summary
    cd16083
    Location:145235
    IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
    cd16086
    Location:39142
    IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38277793..38316682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159758.1XP_036015651.1  T-lymphocyte activation antigen CD80 isoform X1

    Related
    ENSMUSP00000156031.2, ENSMUST00000231716.2
    Conserved Domains (2) summary
    cd16086
    Location:47150
    IgV_CD80; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80
    cd16083
    Location:153243
    IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
  2. XM_030248945.2XP_030104805.1  T-lymphocyte activation antigen CD80 isoform X2

    Related
    ENSMUSP00000156252.2, ENSMUST00000232409.2
    Conserved Domains (1) summary
    cl11960
    Location:47150
    Ig; Immunoglobulin domain
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