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Trim33 tripartite motif-containing 33 [ Mus musculus (house mouse) ]

Gene ID: 94093, updated on 20-Feb-2024

Summary

Official Symbol
Trim33provided by MGI
Official Full Name
tripartite motif-containing 33provided by MGI
Primary source
MGI:MGI:2137357
See related
Ensembl:ENSMUSG00000033014 AllianceGenome:MGI:2137357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ecto; Tif1g; 8030451N04Rik
Summary
Predicted to enable R-SMAD binding activity and co-SMAD binding activity. Predicted to be involved in negative regulation of BMP signaling pathway; protein ubiquitination; and regulation of transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in genitourinary system and submandibular gland primordium. Orthologous to human TRIM33 (tripartite motif containing 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 7.3), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Trim33 in Genome Data Viewer
Location:
3 F2.2; 3 45.25 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103186609..103266086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103279293..103358770)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:102975364-102975665 Neighboring gene STARR-seq mESC enhancer starr_08594 Neighboring gene BCAS2 pre-mRNA processing factor Neighboring gene STARR-seq mESC enhancer starr_08595 Neighboring gene STARR-seq mESC enhancer starr_08596 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103010366-103010667 Neighboring gene predicted gene, 40113 Neighboring gene STARR-seq mESC enhancer starr_08597 Neighboring gene STARR-seq mESC enhancer starr_08598 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103082888-103083189 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103182003-103182304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103190717-103190948 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103201369-103201673 Neighboring gene predicted gene, 25009 Neighboring gene STARR-seq mESC enhancer starr_08599 Neighboring gene predicted gene, 25869

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA1113, DKFZp586K1123

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM33
Names
RING-type E3 ubiquitin transferase TRIM33
TIF1-gamma
ectodermin homolog
transcription intermediary factor 1-gamma
tripartite motif-containing protein 33
NP_001073299.1
NP_444400.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079830.2NP_001073299.1  E3 ubiquitin-protein ligase TRIM33 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC164089, AK129293
    Consensus CDS
    CCDS38574.1
    UniProtKB/Swiss-Prot
    Q6SI71, Q6ZPX5, Q99PP7
    UniProtKB/TrEMBL
    E9QME5
    Related
    ENSMUSP00000102473.2, ENSMUST00000106860.6
    Conserved Domains (6) summary
    cd05502
    Location:9711079
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:333459
    BBC; B-Box C-terminal domain
    smart00336
    Location:226262
    BBOX; B-Box-type zinc finger
    cd00021
    Location:288326
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:138202
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:902947
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
  2. NM_053170.3NP_444400.2  E3 ubiquitin-protein ligase TRIM33 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164089, AY458590
    Consensus CDS
    CCDS38573.1
    UniProtKB/Swiss-Prot
    Q6SI71, Q6ZPX5, Q99PP7
    UniProtKB/TrEMBL
    E9QP19
    Related
    ENSMUSP00000029444.7, ENSMUST00000029444.13
    Conserved Domains (6) summary
    cd05502
    Location:9711096
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:333459
    BBC; B-Box C-terminal domain
    smart00336
    Location:226262
    BBOX; B-Box-type zinc finger
    cd00021
    Location:288326
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:138202
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:902947
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103186609..103266086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954429.2 RNA Sequence

  2. XR_375607.5 RNA Sequence