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TRIM33 tripartite motif containing 33 [ Homo sapiens (human) ]

Gene ID: 51592, updated on 24-Nov-2020

Summary

Official Symbol
TRIM33provided by HGNC
Official Full Name
tripartite motif containing 33provided by HGNC
Primary source
HGNC:HGNC:16290
See related
Ensembl:ENSG00000197323 MIM:605769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA
Summary
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See TRIM33 in Genome Data Viewer
Location:
1p13.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (114392787..114511203, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (114935399..115053781, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L57 pseudogene 1 Neighboring gene trafficking kinesin protein 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2597 Neighboring gene ribosomal protein L26 pseudogene 10 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 5 Neighboring gene uncharacterized LOC105378913 Neighboring gene pyruvate kinase M1/2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants on 1p13.2 associate with risk of autism.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32925

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
co-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM33
Names
RET-fused gene 7 protein
RING-type E3 ubiquitin transferase TRIM33
TIF1-gamma
ectodermin homolog
protein Rfg7
transcriptional intermediary factor 1 gamma
NP_056990.3
NP_148980.2
XP_005270993.1
XP_005270994.1
XP_011539870.1
XP_016856943.1
XP_024303352.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023287.1 RefSeqGene

    Range
    4958..123370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015906.4NP_056990.3  E3 ubiquitin-protein ligase TRIM33 isoform alpha

    See identical proteins and their annotated locations for NP_056990.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (alpha).
    Source sequence(s)
    AB029036, AF119043, AK023434, AL035410, AL390241, CN267696
    Consensus CDS
    CCDS872.1
    UniProtKB/Swiss-Prot
    Q9UPN9
    UniProtKB/TrEMBL
    B3KN30
    Related
    ENSP00000351250.2, ENST00000358465.7
    Conserved Domains (6) summary
    cd05502
    Location:9581083
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:319445
    BBC; B-Box C-terminal domain
    smart00336
    Location:212248
    BBOX; B-Box-type zinc finger
    cd00021
    Location:274312
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:124188
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:889934
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
  2. NM_033020.3NP_148980.2  E3 ubiquitin-protein ligase TRIM33 isoform beta

    See identical proteins and their annotated locations for NP_148980.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks exon 15 of the coding region. The reading frame is maintained and the encoded protein, isoform beta, lacks an internal 17 aa fragment as compared to isoform alpha.
    Source sequence(s)
    AB029036, AF119043, AF220137, AK023434, AL035410, AL390241, CN267696
    Consensus CDS
    CCDS873.1
    UniProtKB/Swiss-Prot
    Q9UPN9
    UniProtKB/TrEMBL
    B3KN30
    Related
    ENSP00000358556.2, ENST00000369543.6
    Conserved Domains (6) summary
    cd05502
    Location:9581066
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:319445
    BBC; B-Box C-terminal domain
    smart00336
    Location:212248
    BBOX; B-Box-type zinc finger
    cd00021
    Location:274312
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:124188
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:889934
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    114392787..114511203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541568.3XP_011539870.1  E3 ubiquitin-protein ligase TRIM33 isoform X2

    Conserved Domains (6) summary
    cd05502
    Location:9811106
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:319445
    BBC; B-Box C-terminal domain
    smart00336
    Location:212248
    BBOX; B-Box-type zinc finger
    cd00021
    Location:274312
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:124188
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:912957
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
  2. XM_005270937.4XP_005270994.1  E3 ubiquitin-protein ligase TRIM33 isoform X3

    Conserved Domains (6) summary
    cd05502
    Location:9821090
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:319445
    BBC; B-Box C-terminal domain
    smart00336
    Location:212248
    BBOX; B-Box-type zinc finger
    cd00021
    Location:274312
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:124188
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:913958
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
  3. XM_005270936.4XP_005270993.1  E3 ubiquitin-protein ligase TRIM33 isoform X1

    Conserved Domains (6) summary
    cd05502
    Location:9821107
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:319445
    BBC; B-Box C-terminal domain
    smart00336
    Location:212248
    BBOX; B-Box-type zinc finger
    cd00021
    Location:274312
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:124188
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15624
    Location:913958
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
  4. XM_024447584.1XP_024303352.1  E3 ubiquitin-protein ligase TRIM33 isoform X5

    Conserved Domains (3) summary
    cd05502
    Location:440565
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    cd15624
    Location:371416
    PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    cl26464
    Location:48268
    Atrophin-1; Atrophin-1 family
  5. XM_017001454.2XP_016856943.1  E3 ubiquitin-protein ligase TRIM33 isoform X4

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