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SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 [ Homo sapiens (human) ]

Gene ID: 93517, updated on 23-Nov-2021

Summary

Official Symbol
SDR42E1provided by HGNC
Official Full Name
short chain dehydrogenase/reductase family 42E, member 1provided by HGNC
Primary source
HGNC:HGNC:29834
See related
Ensembl:ENSG00000184860 MIM:616164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC105
Expression
Broad expression in skin (RPKM 2.8), duodenum (RPKM 2.0) and 17 other tissues See more
Orthologs
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Genomic context

See SDR42E1 in Genome Data Viewer
Location:
16q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (81988855..82011526, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (82022460..82045075, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4151 Neighboring gene phospholipase C gamma 2 Neighboring gene RN7SK pseudogene 176 Neighboring gene uncharacterized LOC112268169 Neighboring gene uncharacterized LOC105371363 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2 Neighboring gene MT-CYB pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of short chain dehydrogenase/reductase family 42E, member 1 (SDR42E1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
short-chain dehydrogenase/reductase family 42E member 1
NP_660151.2
XP_005256314.1
XP_011521773.1
XP_024306261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145168.3NP_660151.2  short-chain dehydrogenase/reductase family 42E member 1

    See identical proteins and their annotated locations for NP_660151.2

    Status: VALIDATED

    Source sequence(s)
    AC092142, AK026740, BC019670, BX482154, CB851753
    Consensus CDS
    CCDS42205.1
    UniProtKB/Swiss-Prot
    Q8WUS8
    Related
    ENSP00000332407.4, ENST00000328945.7
    Conserved Domains (2) summary
    cd09812
    Location:10350
    3b-HSD_like_1_SDR_e; 3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
    pfam01073
    Location:12283
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    81988855..82011526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450493.1XP_024306261.1  short-chain dehydrogenase/reductase family 42E member 1 isoform X2

    Conserved Domains (1) summary
    cd09812
    Location:21347
    3b-HSD_like_1_SDR_e; 3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
  2. XM_005256257.4XP_005256314.1  short-chain dehydrogenase/reductase family 42E member 1 isoform X1

    See identical proteins and their annotated locations for XP_005256314.1

    UniProtKB/Swiss-Prot
    Q8WUS8
    Conserved Domains (2) summary
    cd09812
    Location:10350
    3b-HSD_like_1_SDR_e; 3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
    pfam01073
    Location:12283
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
  3. XM_011523471.3XP_011521773.1  short-chain dehydrogenase/reductase family 42E member 1 isoform X2

    See identical proteins and their annotated locations for XP_011521773.1

    Conserved Domains (1) summary
    cd09812
    Location:21347
    3b-HSD_like_1_SDR_e; 3beta-hydroxysteroid dehydrogenase (3b-HSD)-like, subgroup1, extended (e) SDRs
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