Conserved Protein Domain Family
3Beta_HSD

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pfam01073: 3Beta_HSD (this model, PSSM-Id:279420 is obsolete and has been replaced by 366449)
3-beta hydroxysteroid dehydrogenase/isomerase family
The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyzes the oxidation and isomerisation of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.
Statistics
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PSSM-Id: 279420
Aligned: 9 rows
Threshold Bit Score: 350.503
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q67477      7 VVTGGCGFLGRHIINNLILFESsLKEVRVYD------IRIDQWLldLVEKCNIIki-vPVIGDVRNKSTLDEALRSADVV 79  Fowlpox virus stra...
Q98318      5 AVTGGGGFIGSYIVRALLQCERtLIELRVID------VRWGTKV--SSRNVNVV----YIYCDVCDTARLCAALEGVDVL 72  Molluscum contagio...
P26670      5 AVTGGAGFLGRYIVKLLISADD-VQEIRVID------IVEDPQP--ITSKVKVIn---YIQCDINDFDKVREALDGVNLI 72  Vaccinia virus WR
P14060      7 LVTGAGGFLGQRIIRLLVKEKE-LKEIRVLD------KAFGPELreEFSKLQNKtkltVLEGDILDEPFLKRACQDVSVI 79  human
P24815      7 LVTGAGGFVGQRIIKMLVQEKE-LQEVRALD------KVFRPETkeEFSKLQTKtkvtVLEGDILDAQCLRRACQGISVV 79  house mouse
O22813     15 VVTGGLGFVGAALCLELVRRG--ARQVRSFD------LRHSSPWsdDLKNSGVR----CIQGDVTKKQDVDNALDGADCV 82  thale cress
A9X4U2     16 VVLGGRGFIGRSLVSRLLRLGN--WTVRVADsghtlhLDESDSLleDALSSGRAs---YHCVDVRDKPQIVKVTEGSYVV 90  thale cress
P53199      8 LIIGGSGFLGLHLIQQFFDINP-KPDIHIFD------VRDLPEKlsKQFTFNVDdi-kFHKGDLTSPDDMENAINESKAN 79  Saccharomyces cere...
NP_990449   9 LVTGAGGFLGQRIVRLLLEEDEaLAEIRLLD------KAFSREAlwSFGKFQGKtevkILEGDIRDVEFLHRACQGVSLV 82  chicken
Q67477     80 IHIASINDVAG-KFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIrGNENTYYQSN--HKEAYP 156 Fowlpox virus stra...
Q98318     73 IHTAGLVDVMG-EYSEDEIYRANVHGTHSALSACVCAGVRFVVYTSSMEVVGPNMRAEPFV-GDEKTEYESC--HQHCYP 148 Molluscum contagio...
P26670     73 IHTAALVDVFG-KYTDNEIMKVNYYGTQTILAACVDLGIKYLIYTSSMEAIGPNKHGDPFI-GHEHTLYDIS--PGHVYA 148 Vaccinia virus WR
P14060     80 IHTACIIDVFG-VTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQnGHEEEPLENT--WPAPYP 156 human
P24815     80 IHTAAVIDVTG-VIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLnGHEEQNHEST--WSDPYP 156 house mouse
O22813     83 LHLASYGMSGKeMLRFGRCDEVNINGTCNVLEAAFKHEITRIVYVSTYNVVFG---GKEILnGNEGLPYFPLddHVDAYS 159 thale cress
A9X4U2     91 FYM-GATDLRS-HDYFD-CYKVIVQGTRNVISACRESGVRKLIYNSTADVVFD--GSQPIRdGDESLRRPLK--FQSMLT 163 thale cress
P53199     80 VVVHCASPMHG--QNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFN---GQDVHnADETWPIPEV--PMDAYN 152 Saccharomyces cere...
NP_990449  83 IHTASIIDTLG-LVEKQLLWEVNVTGTQMLLEACAHCNVQHFIYTSTIEVAGPNCRGDPIFnGDEDTPYEST--SKFPYA 159 chicken
Q67477    157 LSKQLSEKYILEANG-TMSNIGlRLCTCALRPLGVFGEYCPVLETLYRRSYKSR-KMYKYADDKVFHSRVYAGNVAWMHI 234 Fowlpox virus stra...
Q98318    149 RSKAEAEELVLSSNGrRVRGGQ-RMLTCALRPPGVYGEGNQLLLRLAKNYVRMGlHVPRTVCENALQSRVYVGNVAWMHV 227 Molluscum contagio...
P26670    149 KSKRMAEQLVMKANNsVIMNGA-KLYTCCLRPTGIYGEGDKLTKVFYEQCKQHGnIMYRTVDDDAVHSRVYVGNVAWMHV 227 Vaccinia virus WR
P14060    157 HSKKLAEKAVLAANGwNLKNGG-TLYTCALRPMYIYGEGSRFLSASINEALNNN-GILSSVGKFSTVNPVYVGNVAWAHI 234 human
P24815    157 YSKKMAEKAVLAANGsMLKNGG-TLNTCALRPMYIYGERSPFIFNAIIRALKNKgILCVTGKFSI-ANPVYVENVAWAHI 234 house mouse
O22813    160 RTKSIAEQLVLKSNGrPFKNGGkRMYTCAIRPAAIYGPGEDRHLPRIVTLTKLGlALFKIGEPSVKSDWIYVENLVLAII 239 thale cress
A9X4U2    164 DFKAQAEALIKLANN---RDG---LLTCALRSSIVFGPGDTEFVPFLVNLAKSGyAKFILGSGENISDFTYSENVSHAHI 237 thale cress
P53199    153 ETKAIAEDMVLKAND-----PSsDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGqSKFQIGDNNNLFDWTYAGNVADAHV 227 Saccharomyces cere...
NP_990449 160 QSKRLAEECVLKADGqMLKDGG-VLVTCALRSMYIFGEGCPFLQGHLDKCLLNKnVYLRFSRKEALVNPVYVGNIAWAHV 238 chicken
Q67477    235 LAARNMIENg----qHSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRNt----CLP 286 Fowlpox virus strain NVSL
Q98318    228 LAARALQEP------DSRLPGNAYFCYDHSPCMDYEAFNVMLLRSFGVELGGp----RLP 277 Molluscum contagiosum virus subtype 1
P26670    228 LAAKYIQYP------GSEIKGNAYFCYDYSPSCSYDMFNLLLMKPLGIEQGSriprwmlk 281 Vaccinia virus WR
P14060    235 LALRALQDPk----kAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSr---wSFP 287 human
P24815    235 LAARGLRDPk----kSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNAs---wSLP 287 house mouse
O22813    240 LASMGLLDDipgregQPVAAGQPYFVSDGYPVN-TFEFLRPLLKSLDYDLPKctisvPFA 298 thale cress
A9X4U2    238 CAVKALDSQ------MEFVAGKEFFITNLKPVR-FWDFVSHIVEGLGYPRPSi----KLP 286 thale cress
P53199    228 LAAQKLLDPk----tRTAVSGETFFITNDTPTY-FWALARTVWKADGHIDKHv---iVLK 279 Saccharomyces cerevisiae S288c
NP_990449 239 QAAKALQVPq----kARHIRGQFYYISDDTPHMSYADLNYELTKELGFGIEPw---lPMP 291 chicken
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