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RPL23 ribosomal protein L23 [ Homo sapiens (human) ]

Gene ID: 9349, updated on 26-Nov-2021

Summary

Official Symbol
RPL23provided by HGNC
Official Full Name
ribosomal protein L23provided by HGNC
Primary source
HGNC:HGNC:10316
See related
Ensembl:ENSG00000125691 MIM:603662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L23; rpL17
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1299.4), bone marrow (RPKM 656.3) and 25 other tissues See more
Orthologs
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Genomic context

See RPL23 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38847860..38853721, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37004113..37009974, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 4727 Neighboring gene chromosome 17 open reading frame 98 Neighboring gene small nucleolar RNA, H/ACA box 21B Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene ribosomal protein S20 pseudogene 35 Neighboring gene tRNA-Cys (anticodon GCA) 14-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein L23 (RPL23), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies a structural ribosomal subunit RPL23 as IN-binding partner PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L23 (RPL23) at amino acid residues 62-63 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC72008, MGC111167, MGC117346

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_positive_effect G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to actinomycin D IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-DNA complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_positive_effect regulation of G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal protein import into nucleus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L23
Names
60S ribosomal protein L17
large ribosomal subunit protein uL14
ribosomal protein L17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000978.4NP_000969.1  60S ribosomal protein L23

    See identical proteins and their annotated locations for NP_000969.1

    Status: REVIEWED

    Source sequence(s)
    AC110749, CA437923, X55954
    Consensus CDS
    CCDS11330.1
    UniProtKB/Swiss-Prot
    P62829
    UniProtKB/TrEMBL
    A0A024R1Q8
    Related
    ENSP00000420311.2, ENST00000479035.7
    Conserved Domains (1) summary
    PTZ00054
    Location:2139
    PTZ00054; 60S ribosomal protein L23; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38847860..38853721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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