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Rpl23 ribosomal protein L23 [ Mus musculus (house mouse) ]

Gene ID: 65019, updated on 5-Mar-2024

Summary

Official Symbol
Rpl23provided by MGI
Official Full Name
ribosomal protein L23provided by MGI
Primary source
MGI:MGI:1929455
See related
Ensembl:ENSMUSG00000071415 AllianceGenome:MGI:1929455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810009A01Rik
Summary
Predicted to enable several functions, including transcription coactivator binding activity; ubiquitin ligase inhibitor activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including cellular response to actinomycin D; negative regulation of nitrogen compound metabolic process; and protein stabilization. Predicted to act upstream of or within translation. Located in nucleolus. Is expressed in several structures, including central nervous system; retina; and uterus. Orthologous to human RPL23 (ribosomal protein L23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 294.5), CNS E11.5 (RPKM 280.5) and 24 other tissues See more
Orthologs
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Genomic context

See Rpl23 in Genome Data Viewer
Location:
11 D; 11 61.1 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97668352..97673265, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97777526..97782439, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA cysteine 18 (anticodon GCA) Neighboring gene sperm microtubule associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5272 Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene STARR-seq mESC enhancer starr_30635 Neighboring gene STARR-positive B cell enhancer ABC_E7052 Neighboring gene nuclear encoded tRNA cysteine 56 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene LIM and SH3 protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_positive_effect G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to actinomycin D ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-DNA complex disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
large ribosomal subunit protein uL14
Names
60S ribosomal protein L23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022891.3NP_075029.1  large ribosomal subunit protein uL14

    See identical proteins and their annotated locations for NP_075029.1

    Status: VALIDATED

    Source sequence(s)
    AK012694, AK018730, CF612967, CN840510
    Consensus CDS
    CCDS25331.1
    UniProtKB/Swiss-Prot
    P62830, Q3THU4, Q9CZE6, Q9DCQ4
    Related
    ENSMUSP00000099435.5, ENSMUST00000103146.5
    Conserved Domains (1) summary
    PTZ00054
    Location:2139
    PTZ00054; 60S ribosomal protein L23; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97668352..97673265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)