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TRIP11 thyroid hormone receptor interactor 11 [ Homo sapiens (human) ]

Gene ID: 9321, updated on 25-Nov-2021

Summary

Official Symbol
TRIP11provided by HGNC
Official Full Name
thyroid hormone receptor interactor 11provided by HGNC
Primary source
HGNC:HGNC:12305
See related
Ensembl:ENSG00000100815 MIM:604505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODCD; ACG1A; CEV14; ODCD1; GMAP210; TRIP-11; TRIP230; GMAP-210
Summary
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in thyroid (RPKM 9.3), kidney (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

See TRIP11 in Genome Data Viewer
Location:
14q32.12
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (91965991..92040134, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (92432335..92506403, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tandem C2 domains, nuclear Neighboring gene fibulin 5 Neighboring gene prothymosin alpha pseudogene 7 Neighboring gene ataxin 3 repeat instability region Neighboring gene ataxin 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Achondrogenesis, type IA
MedGen: C0265273 OMIM: 200600 GeneReviews: Not available
Compare labs
Goldblatt syndrome
MedGen: C2745953 OMIM: 184260 GeneReviews: Not available
Compare labs
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Identification of ten loci associated with height highlights new biological pathways in human growth.
GeneReviews: Not available
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
located_in inner acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in outer acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thyroid receptor-interacting protein 11
Names
Golgi-microtubule-associated protein of 210 kDa
TR-interacting protein 11
clonal evolution-related gene on chromosome 14 protein
golgi-associated microtubule-binding protein 210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016970.1 RefSeqGene

    Range
    5001..79069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321851.1NP_001308780.1  thyroid receptor-interacting protein 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049872
    Conserved Domains (3) summary
    COG1196
    Location:3051074
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:9071751
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15898
    Location:602681
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  2. NM_004239.4NP_004230.2  thyroid receptor-interacting protein 11 isoform 1

    See identical proteins and their annotated locations for NP_004230.2

    Status: REVIEWED

    Source sequence(s)
    AL049872
    Consensus CDS
    CCDS9899.1
    UniProtKB/Swiss-Prot
    Q15643
    Related
    ENSP00000267622.4, ENST00000267622.8
    Conserved Domains (4) summary
    COG1196
    Location:3061075
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:9081752
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10375
    Location:17741819
    GRAB; GRIP-related Arf-binding domain
    cl00081
    Location:64123
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    91965991..92040134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021788.2XP_016877277.1  thyroid receptor-interacting protein 11 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:23793
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:4661310
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15898
    Location:161240
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  2. XM_017021787.2XP_016877276.1  thyroid receptor-interacting protein 11 isoform X1

    Related
    ENSP00000451032.1, ENST00000554357.5

RNA

  1. XR_943560.2 RNA Sequence

  2. XR_001750598.2 RNA Sequence

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