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ZNF235 zinc finger protein 235 [ Homo sapiens (human) ]

Gene ID: 9310, updated on 1-Jun-2020

Summary

Official Symbol
ZNF235provided by HGNC
Official Full Name
zinc finger protein 235provided by HGNC
Primary source
HGNC:HGNC:12866
See related
Ensembl:ENSG00000159917 MIM:604749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF6; ZFP93; ANF270; ZNF270
Summary
This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ZNF235 in Genome Data Viewer
Location:
19q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44286348..44305707, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44790501..44809606, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 227 Neighboring gene zinc finger protein 233 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 1 Neighboring gene zinc finger protein 112 Neighboring gene zinc finger protein 285

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 235
Names
zfp-93
zinc finger protein 270
zinc finger protein 6
zinc finger protein 93 homolog
zinc finger protein HZF6
zinc finger protein homologous to Zfp93 in mouse
zinc finger protein homologous to mouse Zfp93

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004234.4NP_004225.3  zinc finger protein 235

    See identical proteins and their annotated locations for NP_004225.3

    Status: REVIEWED

    Source sequence(s)
    AC092477, AC138470, AC138473
    Consensus CDS
    CCDS33048.1
    UniProtKB/Swiss-Prot
    Q14590
    Related
    ENSP00000291182.3, ENST00000291182.9
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:321662
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:613638
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44286348..44305707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259412.5XP_005259469.1  zinc finger protein 235 isoform X1

    UniProtKB/Swiss-Prot
    Q14590
    Related
    ENSP00000497018.1, ENST00000650576.1
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:317658
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:609634
    zf-H2C2_2; Zinc-finger double domain
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