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SOCS6 suppressor of cytokine signaling 6 [ Homo sapiens (human) ]

Gene ID: 9306, updated on 21-Dec-2019

Summary

Official Symbol
SOCS6provided by HGNC
Official Full Name
suppressor of cytokine signaling 6provided by HGNC
Primary source
HGNC:HGNC:16833
See related
Ensembl:ENSG00000170677 MIM:605118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060
Summary
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 4.2), colon (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See SOCS6 in Genome Data Viewer
Location:
18q22.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (70289045..70330199)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (67956137..67997435)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372180 Neighboring gene uncharacterized LOC107985158 Neighboring gene Sharpr-MPRA regulatory region 10196 Neighboring gene long intergenic non-protein coding RNA 1909 Neighboring gene liver cell viability associated lncRNA Neighboring gene long intergenic non-protein coding RNA 1910

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
suppressor of cytokine signaling 6
Names
STAT induced STAT inhibitor-4
cytokine-inducible SH2 protein 4
suppressor of cytokine signaling 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004232.4NP_004223.2  suppressor of cytokine signaling 6

    See identical proteins and their annotated locations for NP_004223.2

    Status: REVIEWED

    Source sequence(s)
    AC023395, BC020082
    Consensus CDS
    CCDS11998.1
    UniProtKB/Swiss-Prot
    O14544
    UniProtKB/TrEMBL
    A0A024R379
    Related
    ENSP00000381034.3, ENST00000397942.4
    Conserved Domains (2) summary
    cd10387
    Location:373472
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:495535
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    70289045..70330199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026087.1XP_016881576.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/Swiss-Prot
    O14544
    UniProtKB/TrEMBL
    A0A024R379
    Conserved Domains (2) summary
    cd10387
    Location:373472
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:495535
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
  2. XM_005266783.4XP_005266840.1  suppressor of cytokine signaling 6 isoform X1

    See identical proteins and their annotated locations for XP_005266840.1

    UniProtKB/Swiss-Prot
    O14544
    UniProtKB/TrEMBL
    A0A024R379
    Conserved Domains (2) summary
    cd10387
    Location:373472
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:495535
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
  3. XM_017026086.1XP_016881575.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/Swiss-Prot
    O14544
    UniProtKB/TrEMBL
    A0A024R379
    Related
    ENSP00000463395.1, ENST00000582322.1
    Conserved Domains (2) summary
    cd10387
    Location:373472
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:495535
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
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