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Socs6 suppressor of cytokine signaling 6 [ Mus musculus (house mouse) ]

Gene ID: 54607, updated on 24-Sep-2025
Official Symbol
Socs6provided by MGI
Official Full Name
suppressor of cytokine signaling 6provided by MGI
Primary source
MGI:MGI:1924885
See related
Ensembl:ENSMUSG00000056153 AllianceGenome:MGI:1924885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cis4; SSI4; Cish4; STAI4; Socs4; SOCS-4; SOCS-6; STATI4; HSPC060; 1500012M23Rik; 5830401B18Rik
Summary
Predicted to enable signaling adaptor activity. Acts upstream of or within negative regulation of T cell activation and regulation of growth. Predicted to be located in immunological synapse. Is expressed in several structures, including jaw; medulla oblongata basal plate mantle layer; and retina. Orthologous to human SOCS6 (suppressor of cytokine signaling 6). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.2), placenta adult (RPKM 4.8) and 28 other tissues See more
Orthologs
human all
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See Socs6 in Genome Data Viewer
Location:
18 E4; 18 58.66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (88883293..88912623, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (88865169..88894364, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57825 Neighboring gene STARR-seq mESC enhancer starr_45301 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr18:89141017-89141318 Neighboring gene microRNA 6359 Neighboring gene rotatin Neighboring gene CD226 antigen

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism. Li L, et al. J Biol Chem, 2004 Aug 13. PMID 15123678
  2. SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b. Zhang P, et al. Oxid Med Cell Longev, 2022. PMID 35126805, Free PMC Article
  3. Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7. Lawrenson ID, et al. Cereb Cortex, 2017 Jan 1. PMID 26503265
  4. Pim3 negatively regulates glucose-stimulated insulin secretion. Vlacich G, et al. Islets, 2010 Sep-Oct. PMID 21099329, Free PMC Article
  5. Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity. Galic S, et al. Biochem J, 2014 Jul 15. PMID 24966052

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b.
    Title: SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b.
  2. Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
    Title: Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
  3. Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6
    Title: Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.
  4. SOCS6 has a role as a negative regulator of receptor tyrosine kinases
    Title: Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.
  5. TH1-specific chromatin structure is created by early recruitment of Swi-SNF complexes and nucleosome remodeling dependent on Stat4.
    Title: T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
  6. SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
    Title: Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.
  7. SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events.
    Title: Differential roles of SOCS family members in EpoR signal transduction.
  8. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
    Title: SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102463

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
suppressor of cytokine signaling 6
Names
CIS-4
SH2 domain containing SOCS box protein SOCS6
cytokine inducible SH2-containing protein 4
cytokine inducible SH2-containing protein CIS4
cytokine-inducible SH2 protein 4
suppressor of cytokine signaling 4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018821.5 → NP_061291.2  suppressor of cytokine signaling 6

    See identical proteins and their annotated locations for NP_061291.2

    Status: VALIDATED

    Source sequence(s)
    AC122398
    Consensus CDS
    CCDS29389.1
    UniProtKB/Swiss-Prot
    Q8VEN5, Q9D2A0, Q9JLY0
    UniProtKB/TrEMBL
    Q5U469
    Related
    ENSMUSP00000064929.6, ENSMUST00000070116.12
    Conserved Domains (2) summary
    cd10387
    Location:371 → 470
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:493 → 533
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    88883293..88912623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526513.4 → XP_006526576.1  suppressor of cytokine signaling 6 isoform X1

    See identical proteins and their annotated locations for XP_006526576.1

    UniProtKB/Swiss-Prot
    Q8VEN5, Q9D2A0, Q9JLY0
    UniProtKB/TrEMBL
    Q5U469
    Related
    ENSMUSP00000114993.2, ENSMUST00000123826.2
    Conserved Domains (2) summary
    cd10387
    Location:371 → 470
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:493 → 533
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  2. XM_030250541.2 → XP_030106401.1  suppressor of cytokine signaling 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8VEN5, Q9D2A0, Q9JLY0
    UniProtKB/TrEMBL
    Q5U469
    Conserved Domains (2) summary
    cd10387
    Location:371 → 470
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:493 → 533
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  3. XM_011247090.4 → XP_011245392.1  suppressor of cytokine signaling 6 isoform X1

    See identical proteins and their annotated locations for XP_011245392.1

    UniProtKB/Swiss-Prot
    Q8VEN5, Q9D2A0, Q9JLY0
    UniProtKB/TrEMBL
    Q5U469
    Conserved Domains (2) summary
    cd10387
    Location:371 → 470
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:493 → 533
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

  4. XM_011247089.3 → XP_011245391.1  suppressor of cytokine signaling 6 isoform X1

    See identical proteins and their annotated locations for XP_011245391.1

    UniProtKB/Swiss-Prot
    Q8VEN5, Q9D2A0, Q9JLY0
    UniProtKB/TrEMBL
    Q5U469
    Related
    ENSMUSP00000118764.2, ENSMUST00000125362.8
    Conserved Domains (2) summary
    cd10387
    Location:371 → 470
    SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03740
    Location:493 → 533
    SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLY0.2 GenPept UniProtKB/Swiss-Prot:Q9JLY0

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