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SRSF11 serine and arginine rich splicing factor 11 [ Homo sapiens (human) ]

Gene ID: 9295, updated on 3-Nov-2019

Summary

Official Symbol
SRSF11provided by HGNC
Official Full Name
serine and arginine rich splicing factor 11provided by HGNC
Primary source
HGNC:HGNC:10782
See related
Ensembl:ENSG00000116754 MIM:602010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p54; NET2; SFRS11; dJ677H15.2
Summary
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 46.2), skin (RPKM 32.0) and 25 other tissues See more
Orthologs

Genomic context

See SRSF11 in Genome Data Viewer
Location:
1p31.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (70205696..70253052)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (70671365..70717703)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3760 Neighboring gene leucine rich repeat containing 40 Neighboring gene RNA, 7SL, cytoplasmic 242, pseudogene Neighboring gene ankyrin repeat domain 13C Neighboring gene HHLA3 antisense RNA 1 Neighboring gene HERV-H LTR-associating 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18226, DKFZp686M13204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 11
Names
SR splicing factor 11
arginine-rich 54 kDa nuclear protein
splicing factor p54
splicing factor, arginine/serine-rich 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190987.3NP_001177916.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and 5' UTR, compared to variant 1, and encodes an isoform (2) that is one aa shorter than isoform 1. Variants 2 and 5 encode the same protein (isoform 2).
    Source sequence(s)
    AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419
    Consensus CDS
    CCDS53332.1
    UniProtKB/Swiss-Prot
    Q05519
    Related
    ENSP00000359989.1, ENST00000370951.5
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  2. NM_001350605.2NP_001337534.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BF680379, BG494115, CN294419, DA157431, DC415520, M74002
    Consensus CDS
    CCDS647.1
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  3. NM_001350606.2NP_001337535.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CB996573, CN294419, M74002
    Consensus CDS
    CCDS647.1
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  4. NM_001350607.2NP_001337536.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BC040436, BF680379, BG494115, CN294419, M74002
    Consensus CDS
    CCDS53332.1
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  5. NM_001350608.2NP_001337537.1  serine/arginine-rich splicing factor 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, CX869063, M74002
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  6. NM_001350609.2NP_001337538.1  serine/arginine-rich splicing factor 11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, BG612368, CB996573, CN294419, CX869063, M74002
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  7. NM_001350610.2NP_001337539.1  serine/arginine-rich splicing factor 11 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
  8. NM_001350611.2NP_001337540.1  serine/arginine-rich splicing factor 11 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
  9. NM_001350612.2NP_001337541.1  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
  10. NM_001350613.2NP_001337542.1  serine/arginine-rich splicing factor 11 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, CA417788, CN294419, DA157431, DA581964, DC415520
  11. NM_001350614.2NP_001337543.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
  12. NM_001350615.2NP_001337544.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, CX869063, DA157431, DA581964, DC415520
  13. NM_001350616.2NP_001337545.1  serine/arginine-rich splicing factor 11 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL353771, AL532192, BF680379, BG494115, BM716576, BP290987, CA417788, CN294419, DA157431, DA581964, DC415520
  14. NM_004768.5NP_004759.1  serine/arginine-rich splicing factor 11 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AI002238, AL832279, BC022815, BF680379, BG494115, CN294419, M74002
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519
    Related
    ENSP00000359988.3, ENST00000370950.7
    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

RNA

  1. NR_146810.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI002238, AL832279, BF680379, BG494115, BP290987, CD687855, CN294419, DA157431, DC415520, M74002

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    70205696..70253052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542431.2XP_011540733.1  serine/arginine-rich splicing factor 11 isoform X2

  2. XM_005271338.4XP_005271395.1  serine/arginine-rich splicing factor 11 isoform X1

    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  3. XM_024450905.1XP_024306673.1  serine/arginine-rich splicing factor 11 isoform X1

    Conserved Domains (1) summary
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  4. XM_024450912.1XP_024306680.1  serine/arginine-rich splicing factor 11 isoform X3

    Related
    ENSP00000359987.1, ENST00000370949.1
  5. XM_017002819.2XP_016858308.1  serine/arginine-rich splicing factor 11 isoform X5

  6. XM_024450906.1XP_024306674.1  serine/arginine-rich splicing factor 11 isoform X2

  7. XM_011542428.3XP_011540730.1  serine/arginine-rich splicing factor 11 isoform X2

  8. XM_024450908.1XP_024306676.1  serine/arginine-rich splicing factor 11 isoform X3

  9. XM_024450917.1XP_024306685.1  serine/arginine-rich splicing factor 11 isoform X5

  10. XM_017002820.2XP_016858309.1  serine/arginine-rich splicing factor 11 isoform X6

  11. XM_024450922.1XP_024306690.1  serine/arginine-rich splicing factor 11 isoform X7

  12. XM_024450927.1XP_024306695.1  serine/arginine-rich splicing factor 11 isoform X8

  13. XM_017002815.2XP_016858304.1  serine/arginine-rich splicing factor 11 isoform X2

  14. XM_017002817.2XP_016858306.1  serine/arginine-rich splicing factor 11 isoform X5

  15. XM_017002825.2XP_016858314.1  serine/arginine-rich splicing factor 11 isoform X7

  16. XM_017002831.2XP_016858320.1  serine/arginine-rich splicing factor 11 isoform X8

  17. XM_024450923.1XP_024306691.1  serine/arginine-rich splicing factor 11 isoform X7

  18. XM_024450916.1XP_024306684.1  serine/arginine-rich splicing factor 11 isoform X5

  19. XM_024450921.1XP_024306689.1  serine/arginine-rich splicing factor 11 isoform X7

  20. XM_024450925.1XP_024306693.1  serine/arginine-rich splicing factor 11 isoform X8

  21. XM_024450915.1XP_024306683.1  serine/arginine-rich splicing factor 11 isoform X4

RNA

  1. XR_426640.4 RNA Sequence

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