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Srsf11 serine/arginine-rich splicing factor 11 [ Mus musculus (house mouse) ]

Gene ID: 69207, updated on 23-May-2018

Summary

Official Symbol
Srsf11provided by MGI
Official Full Name
serine/arginine-rich splicing factor 11provided by MGI
Primary source
MGI:MGI:1916457
See related
Ensembl:ENSMUSG00000055436 Vega:OTTMUSG00000031923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfrs11; BF642805; 0610009J05Rik; 2610019N13Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Ubiquitous expression in limb E14.5 (RPKM 60.3), CNS E14 (RPKM 43.9) and 28 other tissues See more
Orthologs

Genomic context

See Srsf11 in Genome Data Viewer
Location:
3; 3 H4
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (158010493..158036647, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (157673457..157699603, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene ankyrin repeat domain 13c Neighboring gene leucine rich repeat containing 40 Neighboring gene leucine rich repeat containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 11
Names
splicing factor, arginine/serine-rich 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093752.2NP_001087221.1  serine/arginine-rich splicing factor 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC145301, AK141191, AK146719, AK163152
    Consensus CDS
    CCDS51103.1
    UniProtKB/TrEMBL
    E9Q6E5
    Related
    ENSMUSP00000113685.1, OTTMUSP00000042182, ENSMUST00000121326.7
    Conserved Domains (1) summary
    cd12518
    Location:62141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  2. NM_001093753.2NP_001087222.1  serine/arginine-rich splicing factor 11 isoform 1

    See identical proteins and their annotated locations for NP_001087222.1

    Status: REVIEWED

    Source sequence(s)
    AC145301, AK141191, AK146719
    Consensus CDS
    CCDS51102.1
    UniProtKB/TrEMBL
    Q3UIX4
    Related
    ENSMUSP00000072651.8, OTTMUSP00000042183, ENSMUST00000072875.14
    Conserved Domains (1) summary
    cd12518
    Location:27106
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  3. NM_001356997.1NP_001343926.1  serine/arginine-rich splicing factor 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC145301

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    158010493..158036647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502016.3XP_006502079.1  serine/arginine-rich splicing factor 11 isoform X3

    Conserved Domains (1) summary
    cd12518
    Location:62141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  2. XM_011240219.2XP_011238521.1  serine/arginine-rich splicing factor 11 isoform X2

    Conserved Domains (1) summary
    cd12518
    Location:62141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  3. XM_006502015.3XP_006502078.1  serine/arginine-rich splicing factor 11 isoform X1

    Related
    ENSMUSP00000063916.8, OTTMUSP00000042194, ENSMUST00000069025.13, OTTMUST00000079172
    Conserved Domains (1) summary
    cd12518
    Location:62141
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  4. XM_017319708.1XP_017175197.1  serine/arginine-rich splicing factor 11 isoform X4

    Conserved Domains (1) summary
    cd12518
    Location:27106
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  5. XM_017319710.1XP_017175199.1  serine/arginine-rich splicing factor 11 isoform X7

  6. XM_006502022.1XP_006502085.1  serine/arginine-rich splicing factor 11 isoform X6

  7. XM_006502020.3XP_006502083.1  serine/arginine-rich splicing factor 11 isoform X5

  8. XM_017319709.1XP_017175198.1  serine/arginine-rich splicing factor 11 isoform X6

  9. XM_017319711.1XP_017175200.1  serine/arginine-rich splicing factor 11 isoform X8

RNA

  1. XR_001783740.1 RNA Sequence

  2. XR_375573.3 RNA Sequence

  3. XR_001783741.1 RNA Sequence

  4. XR_375574.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026989.3: Suppressed sequence

    Description
    NM_026989.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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