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ZNF276 zinc finger protein 276 [ Homo sapiens (human) ]

Gene ID: 92822, updated on 21-Dec-2019

Summary

Official Symbol
ZNF276provided by HGNC
Official Full Name
zinc finger protein 276provided by HGNC
Primary source
HGNC:HGNC:23330
See related
Ensembl:ENSG00000158805 MIM:608460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZADT; CENPZ; CENP-Z; ZFP276; ZNF477
Expression
Ubiquitous expression in lymph node (RPKM 7.7), spleen (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF276 in Genome Data Viewer
Location:
16q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89720368..89740925)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89786393..89807333)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 2 like Neighboring gene VPS9D1 antisense RNA 1 Neighboring gene VPS9 domain containing 1 Neighboring gene FA complementation group A Neighboring gene Sharpr-MPRA regulatory region 3988 Neighboring gene uncharacterized LOC107984817 Neighboring gene spire type actin nucleation factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31843, FLJ38685, FLJ59696, FLJ77809, MGC45417, MGC111410, MGC126479, MGC126480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 276
Names
centromere protein Z
zinc finger protein 276 homolog
zinc finger protein 477
zinc finger, AD-type

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113525.2NP_001106997.1  zinc finger protein 276 isoform a

    See identical proteins and their annotated locations for NP_001106997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (a).
    Source sequence(s)
    AC010538, AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA891371
    Consensus CDS
    CCDS45554.1
    UniProtKB/Swiss-Prot
    Q8N554
    UniProtKB/TrEMBL
    I6L9I3
    Related
    ENSP00000415836.2, ENST00000443381.7
    Conserved Domains (3) summary
    sd00017
    Location:470490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:496518
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:79155
    zf-AD; Zinc-finger associated domain (zf-AD)
  2. NM_152287.4NP_689500.2  zinc finger protein 276 isoform b

    See identical proteins and their annotated locations for NP_689500.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has an alternate 5' exon and initiates translation at a downstream AUG start codon, compared to variant a. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA227038
    Consensus CDS
    CCDS10986.1
    UniProtKB/Swiss-Prot
    Q8N554
    UniProtKB/TrEMBL
    I6L9I3
    Related
    ENSP00000289816.5, ENST00000289816.9
    Conserved Domains (3) summary
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:421443
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:480
    zf-AD; Zinc-finger associated domain (zf-AD)

RNA

  1. NR_110122.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) has an alternate 5' exon and an additional segment in the 3' region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, AK056405, AK289801, BC105959, BM972950, DA227038
  2. NR_110126.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, BC105959, BM972950, DA227038
  3. NR_110128.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK289801, BC105959, BM972950, DA523531
    Related
    ENST00000563983.5
  4. NR_110129.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) has an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, AC010538, AK026482, BC105959, BM972950, DA891371, HY040533

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89720368..89740925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256324.3XP_005256381.1  zinc finger protein 276 isoform X1

    See identical proteins and their annotated locations for XP_005256381.1

    Conserved Domains (4) summary
    PHA02682
    Location:144282
    PHA02682; ORF080 virion core protein; Provisional
    sd00017
    Location:453473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479501
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:79155
    zf-AD; Zinc-finger associated domain (zf-AD)
  2. XM_017023889.1XP_016879378.1  zinc finger protein 276 isoform X2

    Related
    ENSP00000457313.1, ENST00000568295.5
  3. XM_017023890.1XP_016879379.1  zinc finger protein 276 isoform X3

    UniProtKB/TrEMBL
    A8K186
    Conserved Domains (2) summary
    sd00017
    Location:256276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
  4. XM_005256328.3XP_005256385.1  zinc finger protein 276 isoform X3

    See identical proteins and their annotated locations for XP_005256385.1

    UniProtKB/TrEMBL
    A8K186
    Conserved Domains (2) summary
    sd00017
    Location:256276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. XR_933484.2 RNA Sequence

  2. XR_429740.2 RNA Sequence

  3. XR_001752030.1 RNA Sequence

  4. XR_002957853.1 RNA Sequence

  5. XR_001752031.1 RNA Sequence

  6. XR_243507.2 RNA Sequence

  7. XR_001752032.1 RNA Sequence

  8. XR_001752029.1 RNA Sequence

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