U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF276 zinc finger protein 276 [ Homo sapiens (human) ]

Gene ID: 92822, updated on 6-Jul-2026
Official Symbol
ZNF276provided by HGNC
Official Full Name
zinc finger protein 276provided by HGNC
Primary source
HGNC:HGNC:23330
See related
Ensembl:ENSG00000158805 MIM:608460; AllianceGenome:HGNC:23330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZADT; CENPZ; CENP-Z; ZFP276; ZNF477
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in kinetochore. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in lymph node (RPKM 7.7), spleen (RPKM 7.6) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZNF276 in Genome Data Viewer
Location:
16q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89720368..89740925)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95805134..95825676)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89786776..89807333)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89765851-89766716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89772795-89773295 Neighboring gene spermatogenesis associated 2 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89777095-89777658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11419 Neighboring gene VPS9D1 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7924 Neighboring gene VPS9 domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89795065-89795636 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46690 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46704 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46706 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46707/46708 Neighboring gene MPRA-validated peak2667 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46713 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46714 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46718 Neighboring gene FA complementation group A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11421 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:89846248-89846785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89872952-89873474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7925 Neighboring gene Sharpr-MPRA regulatory region 3988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11422 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7927 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:89900233-89901432 Neighboring gene uncharacterized LOC124903760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89903444-89904066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89904067-89904688 Neighboring gene spire type actin nucleation factor 2 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 16:89913406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89913685-89914304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89914305-89914923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920364-89920864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89920865-89921365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11425 Neighboring gene uncharacterized LOC112268179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89938758-89939714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7928

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. Wong JCY, et al. J Hum Genet, 2003. PMID 14605947
  2. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Wong JC, et al. Genomics, 2000 Aug 1. PMID 10936049
  3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31843, FLJ38685, FLJ59696, FLJ77809, MGC45417, MGC111410, MGC126479, MGC126480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 276
Names
centromere protein Z
zinc finger protein 276 homolog
zinc finger protein 477
zinc finger, AD-type

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113525.2 → NP_001106997.1  zinc finger protein 276 isoform a

    See identical proteins and their annotated locations for NP_001106997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (a).
    Source sequence(s)
    AC010538, AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA891371
    Consensus CDS
    CCDS45554.1
    UniProtKB/Swiss-Prot
    Q0VGA1, Q2TBE8, Q3B7H7, Q8N554
    Related
    ENSP00000415836.2, ENST00000443381.7
    Conserved Domains (3) summary
    sd00017
    Location:470 → 490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:496 → 518
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:79 → 155
    zf-AD; Zinc-finger associated domain (zf-AD)

  2. NM_152287.4 → NP_689500.2  zinc finger protein 276 isoform b

    See identical proteins and their annotated locations for NP_689500.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has an alternate 5' exon and initiates translation at a downstream AUG start codon, compared to variant a. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF354756, AI283548, AK096004, AK096762, BC105959, BC107603, BC110348, BQ432535, BQ549716, DA227038
    Consensus CDS
    CCDS10986.1
    UniProtKB/TrEMBL
    B4DIT3
    Related
    ENSP00000289816.5, ENST00000289816.9
    Conserved Domains (3) summary
    sd00017
    Location:395 → 415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:421 → 443
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:4 → 80
    zf-AD; Zinc-finger associated domain (zf-AD)

RNA

  1. NR_110122.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) has an alternate 5' exon and an additional segment in the 3' region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, AK056405, AK289801, BC105959, BM972950, DA227038

  2. NR_110126.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, BC105959, BM972950, DA227038

  3. NR_110128.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) has an alternate 5' exon and an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, AK289801, BC105959, BM972950, DA523531

  4. NR_110129.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) has an alternate splice site in an internal region, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005360, AC010538, AK026482, BC105959, BM972950, DA891371, HY040533

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    89720368..89740925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434901.1 → XP_047290857.1  zinc finger protein 276 isoform X2

    UniProtKB/TrEMBL
    B4DIT3

  2. XM_005256324.4 → XP_005256381.1  zinc finger protein 276 isoform X1

    See identical proteins and their annotated locations for XP_005256381.1

    UniProtKB/TrEMBL
    A0ACI8SH66, A0ACI8STI9
    Related
    ENSP00000576619.1, ENST00000906560.1
    Conserved Domains (4) summary
    PHA02682
    Location:144 → 282
    PHA02682; ORF080 virion core protein; Provisional
    sd00017
    Location:453 → 473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 501
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:79 → 155
    zf-AD; Zinc-finger associated domain (zf-AD)

  3. XM_047434902.1 → XP_047290858.1  zinc finger protein 276 isoform X3

    UniProtKB/TrEMBL
    B3KPI7

  4. XM_017023889.2 → XP_016879378.1  zinc finger protein 276 isoform X4

    UniProtKB/TrEMBL
    H3BTT0

  5. XM_047434903.1 → XP_047290859.1  zinc finger protein 276 isoform X5

  6. XM_047434905.1 → XP_047290861.1  zinc finger protein 276 isoform X6

    Related
    ENSP00000457313.1, ENST00000568295.5

RNA

  1. XR_007064929.1 RNA Sequence

  2. XR_933484.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    95805134..95825676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314379.1 → XP_054170354.1  zinc finger protein 276 isoform X2

    UniProtKB/TrEMBL
    B4DIT3

  2. XM_054314378.1 → XP_054170353.1  zinc finger protein 276 isoform X1

    UniProtKB/TrEMBL
    A0ACI8SH66, A0ACI8STI9

  3. XM_054314380.1 → XP_054170355.1  zinc finger protein 276 isoform X3

    UniProtKB/TrEMBL
    B3KPI7

  4. XM_054314381.1 → XP_054170356.1  zinc finger protein 276 isoform X6

RNA

  1. XR_008484747.1 RNA Sequence

  2. XR_008484750.1 RNA Sequence

  3. XR_008484748.1 RNA Sequence

  4. XR_008484749.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N554.4 GenPept UniProtKB/Swiss-Prot:Q8N554

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools