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DNER delta/notch like EGF repeat containing [ Homo sapiens (human) ]

Gene ID: 92737, updated on 21-Dec-2019

Summary

Official Symbol
DNERprovided by HGNC
Official Full Name
delta/notch like EGF repeat containingprovided by HGNC
Primary source
HGNC:HGNC:24456
See related
Ensembl:ENSG00000187957 MIM:607299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bet; UNQ26
Expression
Biased expression in brain (RPKM 69.6), adrenal (RPKM 34.4) and 2 other tissues See more
Orthologs

Genomic context

See DNER in Genome Data Viewer
Location:
2q36.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (229357629..229714555, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230222345..230579286, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene phosphotyrosine interaction domain containing 1 Neighboring gene RN7SK pseudogene 283 Neighboring gene PID1-DNER intergenic CAGE-defined monocyte enhancer Neighboring gene uncharacterized LOC107985994 Neighboring gene DNER intron CAGE-defined monocyte enhancer Neighboring gene uncharacterized LOC105373923 Neighboring gene RNA, U7 small nuclear 9 pseudogene Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene F-box protein 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of delta/notch-like EGF repeat containing (DNER) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
clathrin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
endocytosis NAS
Non-traceable Author Statement
more info
PubMed 
glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neuron migration NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta and Notch-like epidermal growth factor-related receptor
Names
H_NH0150O02.1
WUGSC:H_NH0150O02.1
delta-notch-like EGF repeat-containing transmembrane

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139072.4NP_620711.3  delta and Notch-like epidermal growth factor-related receptor precursor

    See identical proteins and their annotated locations for NP_620711.3

    Status: VALIDATED

    Source sequence(s)
    BC024766, BC035009, DA115906, DA400901
    Consensus CDS
    CCDS33390.1
    UniProtKB/Swiss-Prot
    Q8NFT8
    Related
    ENSP00000345229.4, ENST00000341772.5
    Conserved Domains (1) summary
    cd00054
    Location:581617
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    229357629..229714555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246950.3XP_005247007.1  delta and Notch-like epidermal growth factor-related receptor isoform X1

    Conserved Domains (1) summary
    cd00054
    Location:540576
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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