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DNER delta/notch like EGF repeat containing [ Homo sapiens (human) ]

Gene ID: 92737, updated on 3-May-2025
Official Symbol
DNERprovided by HGNC
Official Full Name
delta/notch like EGF repeat containingprovided by HGNC
Primary source
HGNC:HGNC:24456
See related
Ensembl:ENSG00000187957 MIM:607299; AllianceGenome:HGNC:24456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bet; UNQ26
Summary
Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in brain (RPKM 69.6), adrenal (RPKM 34.4) and 2 other tissues See more
Orthologs
NEW
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See DNER in Genome Data Viewer
Location:
2q36.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (229357629..229714555, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (229840190..230197123, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230222345..230579271, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 14 Neighboring gene phosphotyrosine interaction domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 3439 Neighboring gene RN7SK pseudogene 283 Neighboring gene PID1-DNER intergenic CAGE-defined monocyte enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:230271779-230272978 Neighboring gene uncharacterized LOC124907995 Neighboring gene uncharacterized LOC107985994 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230278032-230278250 Neighboring gene NANOG hESC enhancer GRCh37_chr2:230351166-230351667 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105373923 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230488203-230488702 Neighboring gene RNA, U7 small nuclear 9 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579954-230580727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579179-230579953 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230591371-230591872 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:230608102-230608922 Neighboring gene MPRA-validated peak4073 silencer Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230714872-230715551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230715552-230716230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230765063-230765564 Neighboring gene MPRA-validated peak4074 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230785780-230786280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230786281-230786781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17206 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene F-box protein 36

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of delta/notch-like EGF repeat containing (DNER) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables clathrin binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endocytosis NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
delta and Notch-like epidermal growth factor-related receptor
Names
H_NH0150O02.1
WUGSC:H_NH0150O02.1
delta-notch-like EGF repeat-containing transmembrane

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139072.4NP_620711.3  delta and Notch-like epidermal growth factor-related receptor precursor

    See identical proteins and their annotated locations for NP_620711.3

    Status: VALIDATED

    Source sequence(s)
    BC024766, BC035009, DA115906, DA400901
    Consensus CDS
    CCDS33390.1
    UniProtKB/Swiss-Prot
    A6NP39, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8NFT8, Q8TB42, Q9NTF1, Q9UDM2
    UniProtKB/TrEMBL
    A8K0I8
    Related
    ENSP00000345229.4, ENST00000341772.5
    Conserved Domains (1) summary
    cd00054
    Location:581617
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    229357629..229714555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    229840190..230197123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)