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Dner delta/notch-like EGF repeat containing [ Mus musculus (house mouse) ]

Gene ID: 227325, updated on 13-May-2024

Summary

Official Symbol
Dnerprovided by MGI
Official Full Name
delta/notch-like EGF repeat containingprovided by MGI
Primary source
MGI:MGI:2152889
See related
Ensembl:ENSMUSG00000036766 AllianceGenome:MGI:2152889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BET; Bret; A930026D19Rik
Summary
Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 74.8), CNS E18 (RPKM 57.7) and 6 other tissues See more
Orthologs
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Genomic context

See Dner in Genome Data Viewer
Location:
1 C5; 1 43.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (84347560..84673942, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (84369839..84696221, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphotyrosine interaction domain containing 1 Neighboring gene peptidyl-tRNA hydrolase 2 pseudogene Neighboring gene microRNA 6353 Neighboring gene STARR-seq mESC enhancer starr_01507 Neighboring gene STARR-seq mESC enhancer starr_01508 Neighboring gene STARR-seq mESC enhancer starr_01510 Neighboring gene STARR-seq mESC enhancer starr_01511 Neighboring gene STARR-seq mESC enhancer starr_01512 Neighboring gene STARR-seq mESC enhancer starr_01514 Neighboring gene STARR-seq mESC enhancer starr_01515 Neighboring gene predicted gene, 57795 Neighboring gene microRNA 5126 Neighboring gene predicted gene, 51637 Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene STARR-seq mESC enhancer starr_01519 Neighboring gene F-box protein 36

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC39059

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
delta and Notch-like epidermal growth factor-related receptor
Names
brain EGF repeat-containing transmembrane protein
delta/notch-like EGF-related receptor
transmembrane protein Bet

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152915.1NP_690879.1  delta and Notch-like epidermal growth factor-related receptor precursor

    See identical proteins and their annotated locations for NP_690879.1

    Status: PROVISIONAL

    Source sequence(s)
    BC034634
    Consensus CDS
    CCDS15105.1
    UniProtKB/Swiss-Prot
    Q3U697, Q8JZM4, Q8R226, Q8R4T6, Q8VD97
    Related
    ENSMUSP00000042927.7, ENSMUST00000049126.13
    Conserved Domains (1) summary
    cd00054
    Location:581617
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    84347560..84673942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)