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CD8A CD8a molecule [ Homo sapiens (human) ]

Gene ID: 925, updated on 8-Dec-2018

Summary

Official Symbol
CD8Aprovided by HGNC
Official Full Name
CD8a moleculeprovided by HGNC
Primary source
HGNC:HGNC:1706
See related
Ensembl:ENSG00000153563 MIM:186910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD8; p32; Leu2
Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in spleen (RPKM 38.0), lymph node (RPKM 12.5) and 8 other tissues See more
Orthologs

Genomic context

See CD8A in Genome Data Viewer
Location:
2p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (86784605..86808396, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87011728..87035519, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene uncharacterized LOC105374845 Neighboring gene ring finger protein 103 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene CD8A intronic regulatory region Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8b molecule Neighboring gene anaphase promoting complex subunit 1 pseudogene 1 Neighboring gene WW domain binding protein 1 pseudogene Neighboring gene RANBP2-like and GRIP domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 cytoplasmic tail length determines interaction with CD8A; the presence of an amphipathic sequence in the HIV-1 Env cytoplasmic tail possibly modulates viral receptor specificity by inducing conformational changes in gp120 PubMed
Nef nef HIV-1 Nef co-localizes with CD8-CD3 zeta on the HEK293 cell surface PubMed
nef beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
nef HIV-inoculated and HIV-1 Nef-treated human peripheral blood lymphocytes downregulate cell surface CD8, and this down-modulation could inhibit anti-HIV cytotoxicity associated with cytotoxic T-cell function PubMed
Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I protein binding NAS
Non-traceable Author Statement
more info
PubMed 
coreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation NAS
Non-traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytotoxic T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
T cell receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-cell surface glycoprotein CD8 alpha chain
Names
CD8 antigen, alpha polypeptide (p32)
Leu2 T-lymphocyte antigen
OKT8 T-cell antigen
T cell co-receptor
T-cell antigen Leu2
T-lymphocyte differentiation antigen T8/Leu-2
T8 T-cell antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011608.2 RefSeqGene

    Range
    5001..28792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_44

mRNA and Protein(s)

  1. NM_001145873.1NP_001139345.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001139345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 3 encode the longer, membrane associated isoform (1).
    Source sequence(s)
    AA668685, AK124156, BC025715, DA075688
    Consensus CDS
    CCDS1992.1
    UniProtKB/Swiss-Prot
    P01732
    UniProtKB/TrEMBL
    Q6ZVS2, Q8TAW8
    Related
    ENSP00000386559.2, ENST00000409511.6
    Conserved Domains (2) summary
    cd05720
    Location:31133
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:28128
    IG_like; Immunoglobulin like
  2. NM_001768.6NP_001759.3  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001759.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer, membrane associated isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC064848, AK124156, BC025715, DB129686
    Consensus CDS
    CCDS1992.1
    UniProtKB/Swiss-Prot
    P01732
    UniProtKB/TrEMBL
    Q6ZVS2, Q8TAW8
    Related
    ENSP00000283635.3, ENST00000283635.7
    Conserved Domains (2) summary
    cd05720
    Location:31133
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:28128
    IG_like; Immunoglobulin like
  3. NM_171827.3NP_741969.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_741969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) lacks an internal segment including the transmembrane domain compared to isoform 1, resulting in a secreted protein.
    Source sequence(s)
    AC064848, BC025715, DB129686
    Consensus CDS
    CCDS1993.1
    UniProtKB/Swiss-Prot
    P01732
    UniProtKB/TrEMBL
    Q8TAW8
    Related
    ENSP00000321631.3, ENST00000352580.7
    Conserved Domains (2) summary
    cd05720
    Location:31133
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:28128
    IG_like; Immunoglobulin like

RNA

  1. NR_027353.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' splice pattern, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC064848, AK300089, BC025715, DB129686

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    86784605..86808396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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