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Cd8a CD8 subunit alpha [ Mus musculus (house mouse) ]

Gene ID: 12525, updated on 11-Jun-2024

Summary

Official Symbol
Cd8aprovided by MGI
Official Full Name
CD8 subunit alphaprovided by MGI
Primary source
MGI:MGI:88346
See related
Ensembl:ENSMUSG00000053977 AllianceGenome:MGI:88346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-2; Ly-B; Ly-35; Lyt-2
Summary
Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward thymus adult (RPKM 213.1) See more
Orthologs
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Genomic context

See Cd8a in Genome Data Viewer
Location:
6 C1; 6 32.14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71350411..71356155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71373427..71379171)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71266617-71266800 Neighboring gene predicted gene, 38828 Neighboring gene CD8 subunit beta 1 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIV Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene STARR-positive B cell enhancer ABC_E343 Neighboring gene predicted gene, 30582

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (10)  1 citation
  • Not Applicable (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD8 alpha chain
Names
CD8 antigen, alpha chain
Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
T-cell surface glycoprotein Lyt-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081110.2NP_001074579.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001074579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS39507.1
    UniProtKB/Swiss-Prot
    P01731
    UniProtKB/TrEMBL
    Q542K6
    Related
    ENSMUSP00000068123.8, ENSMUST00000066747.14
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like
  2. NM_009857.1NP_033987.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_033987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS51806.1
    UniProtKB/TrEMBL
    Q8C2L1, Q8CAX3
    Related
    ENSMUSP00000131873.2, ENSMUST00000172321.3
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71350411..71356155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)