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Cd8a CD8 antigen, alpha chain [ Mus musculus (house mouse) ]

Gene ID: 12525, updated on 30-Nov-2021

Summary

Official Symbol
Cd8aprovided by MGI
Official Full Name
CD8 antigen, alpha chainprovided by MGI
Primary source
MGI:MGI:88346
See related
Ensembl:ENSMUSG00000053977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
Expression
Restricted expression toward thymus adult (RPKM 213.1) See more
Orthologs
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Genomic context

See Cd8a in Genome Data Viewer
Location:
6 C1; 6 32.14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71350411..71356155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71373427..71379171)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (71323421..71329165)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CD8 antigen, beta chain 1 Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIV Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene predicted gene, 30582

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD8 alpha chain
Names
Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
T-cell surface glycoprotein Lyt-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081110.2NP_001074579.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001074579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS39507.1
    UniProtKB/Swiss-Prot
    P01731
    Related
    ENSMUSP00000068123.8, ENSMUST00000066747.14
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like
  2. NM_009857.1NP_033987.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_033987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region resulting in a frameshift, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC160090
    Consensus CDS
    CCDS51806.1
    UniProtKB/TrEMBL
    Q8CAX3
    Related
    ENSMUSP00000131873.2, ENSMUST00000172321.3
    Conserved Domains (2) summary
    cd05720
    Location:41147
    Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    smart00410
    Location:38142
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71350411..71356155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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