Format

Send to:

Choose Destination

VAPA VAMP associated protein A [ Homo sapiens (human) ]

Gene ID: 9218, updated on 24-Nov-2020

Summary

Official Symbol
VAPAprovided by HGNC
Official Full Name
VAMP associated protein Aprovided by HGNC
Primary source
HGNC:HGNC:12648
See related
Ensembl:ENSG00000101558 MIM:605703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAP-A; VAP33; VAP-33; hVAP-33
Summary
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 26.8), brain (RPKM 22.1) and 25 other tissues See more
Orthologs

Genomic context

See VAPA in Genome Data Viewer
Location:
18p11.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (9914016..9960021)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (9913955..9960018)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371982 Neighboring gene Sharpr-MPRA regulatory region 4522 Neighboring gene thioredoxin domain containing 2 Neighboring gene RNA, 5S ribosomal pseudogene 450 Neighboring gene uncharacterized LOC105371983 Neighboring gene uncharacterized LOC105371984

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with VAMP (vesicle-associated membrane protein)-associated protein A (VAPA) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FFAT motif binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
FFAT motif binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
cadherin binding HDA PubMed 
microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
colocalizes_with bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum HDA PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
NOT endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vesicle-associated membrane protein-associated protein A
Names
33 kDa VAMP-associated protein
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAMP-A
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003574.6NP_003565.4  vesicle-associated membrane protein-associated protein A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC006238, AF154847, BG488667, BP209270
    Consensus CDS
    CCDS11847.2
    UniProtKB/Swiss-Prot
    Q9P0L0
    Related
    ENSP00000345656.4, ENST00000340541.4
    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain
  2. NM_194434.3NP_919415.2  vesicle-associated membrane protein-associated protein A isoform 2

    See identical proteins and their annotated locations for NP_919415.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC006238, BC002992, BP209270
    Consensus CDS
    CCDS11848.2
    UniProtKB/Swiss-Prot
    Q9P0L0
    Related
    ENSP00000382880.2, ENST00000400000.6
    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    9914016..9960021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451287.1XP_024307055.1  vesicle-associated membrane protein-associated protein A isoform X3

    Conserved Domains (1) summary
    cl27657
    Location:140
    Motile_Sperm; MSP (Major sperm protein) domain
  2. XM_017026079.1XP_016881568.1  vesicle-associated membrane protein-associated protein A isoform X2

  3. XM_011525769.3XP_011524071.1  vesicle-associated membrane protein-associated protein A isoform X1

    Conserved Domains (2) summary
    COG5066
    Location:15199
    SCS2; VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and secretion]
    pfam00635
    Location:20105
    Motile_Sperm; MSP (Major sperm protein) domain
Support Center