U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vapa vesicle-associated membrane protein, associated protein A [ Mus musculus (house mouse) ]

Gene ID: 30960, updated on 24-Jan-2023

Summary

Official Symbol
Vapaprovided by MGI
Official Full Name
vesicle-associated membrane protein, associated protein Aprovided by MGI
Primary source
MGI:MGI:1353561
See related
Ensembl:ENSMUSG00000024091 AllianceGenome:MGI:1353561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
33kDa; VAP-A; VAP33; VAMP-A; VAP-33
Summary
Predicted to enable several functions, including FFAT motif binding activity; identical protein binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including COPII-coated vesicle budding; modulation by host of viral genome replication; and protein localization to endoplasmic reticulum. Located in endoplasmic reticulum and microtubule cytoskeleton. Orthologous to human VAPA (VAMP associated protein A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 108.3), adrenal adult (RPKM 93.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vapa in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65887048..65925441, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65580053..65616462, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35400 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene RAB31, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FFAT motif binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FFAT motif binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding ISO
Inferred from Sequence Orthology
more info
 
involved_in cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingomyelin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein-associated protein A
Names
33 kDa VAMP-associated protein
VAMP-associated protein A
synaptobrevin-associated protein of 33kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355402.1NP_001342331.1  vesicle-associated membrane protein-associated protein A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166058, CT030729
    Related
    ENSMUSP00000156845.2, ENSMUST00000232686.2
    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain
  2. NM_013933.3NP_038961.2  vesicle-associated membrane protein-associated protein A isoform 2

    See identical proteins and their annotated locations for NP_038961.2

    Status: VALIDATED

    Source sequence(s)
    AK167381, BM899396
    Consensus CDS
    CCDS37677.1
    UniProtKB/Swiss-Prot
    Q9QY77, Q9WV55
    UniProtKB/TrEMBL
    A0A6P5R9F0
    Related
    ENSMUSP00000024897.9, ENSMUST00000024897.10
    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65887048..65925441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160637.1XP_036016530.1  vesicle-associated membrane protein-associated protein A isoform X2

    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain
  2. XM_017317500.3XP_017172989.1  vesicle-associated membrane protein-associated protein A isoform X1

    Conserved Domains (1) summary
    pfam00635
    Location:14118
    Motile_Sperm; MSP (Major sperm protein) domain